Frontiers in Immunology (Feb 2018)
Vγ4 T Cells Inhibit the Pro-healing Functions of Dendritic Epidermal T Cells to Delay Skin Wound Closure Through IL-17A
- Yashu Li,
- Yangping Wang,
- Lina Zhou,
- Meixi Liu,
- Meixi Liu,
- Guangping Liang,
- Rongshuai Yan,
- Yufeng Jiang,
- Jianlei Hao,
- Xiaorong Zhang,
- Xiaorong Zhang,
- Xiaohong Hu,
- Xiaohong Hu,
- Yong Huang,
- Yong Huang,
- Rupeng Wang,
- Zhinan Yin,
- Jun Wu,
- Jun Wu,
- Jun Wu,
- Gaoxing Luo,
- Gaoxing Luo,
- Weifeng He,
- Weifeng He
Affiliations
- Yashu Li
- State Key Laboratory of Trauma, Burn and Combined Injury, Institute of Burn Research, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, China
- Yangping Wang
- State Key Laboratory of Trauma, Burn and Combined Injury, Institute of Burn Research, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, China
- Lina Zhou
- Department of Endocrinology, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, China
- Meixi Liu
- State Key Laboratory of Trauma, Burn and Combined Injury, Institute of Burn Research, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, China
- Meixi Liu
- Chongqing Key Laboratory for Disease Proteomics, Department of Endocrinology of Southwest Hospital, Chongqing, China
- Guangping Liang
- State Key Laboratory of Trauma, Burn and Combined Injury, Institute of Burn Research, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, China
- Rongshuai Yan
- State Key Laboratory of Trauma, Burn and Combined Injury, Institute of Burn Research, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, China
- Yufeng Jiang
- Wound Healing Center, Medical School of Chinese PLA, Chinese PLA General Hospital, Beijing, China
- Jianlei Hao
- Biomedical Translational Research Institute, Guangdong Province Key Laboratory of Molecular Immunology and Antibody Engineering, Jinan University, Guangzhou, China
- Xiaorong Zhang
- State Key Laboratory of Trauma, Burn and Combined Injury, Institute of Burn Research, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, China
- Xiaorong Zhang
- Chongqing Key Laboratory for Disease Proteomics, Department of Endocrinology of Southwest Hospital, Chongqing, China
- Xiaohong Hu
- State Key Laboratory of Trauma, Burn and Combined Injury, Institute of Burn Research, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, China
- Xiaohong Hu
- Chongqing Key Laboratory for Disease Proteomics, Department of Endocrinology of Southwest Hospital, Chongqing, China
- Yong Huang
- State Key Laboratory of Trauma, Burn and Combined Injury, Institute of Burn Research, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, China
- Yong Huang
- Chongqing Key Laboratory for Disease Proteomics, Department of Endocrinology of Southwest Hospital, Chongqing, China
- Rupeng Wang
- Department of Dermatology, Xinqiao Hospital, Third Military Medical University (Army Medical University), Chongqing, China
- Zhinan Yin
- Biomedical Translational Research Institute, Guangdong Province Key Laboratory of Molecular Immunology and Antibody Engineering, Jinan University, Guangzhou, China
- Jun Wu
- State Key Laboratory of Trauma, Burn and Combined Injury, Institute of Burn Research, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, China
- Jun Wu
- Chongqing Key Laboratory for Disease Proteomics, Department of Endocrinology of Southwest Hospital, Chongqing, China
- Jun Wu
- Department of Burns, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China
- Gaoxing Luo
- State Key Laboratory of Trauma, Burn and Combined Injury, Institute of Burn Research, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, China
- Gaoxing Luo
- Chongqing Key Laboratory for Disease Proteomics, Department of Endocrinology of Southwest Hospital, Chongqing, China
- Weifeng He
- State Key Laboratory of Trauma, Burn and Combined Injury, Institute of Burn Research, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, China
- Weifeng He
- Chongqing Key Laboratory for Disease Proteomics, Department of Endocrinology of Southwest Hospital, Chongqing, China
- DOI
- https://doi.org/10.3389/fimmu.2018.00240
- Journal volume & issue
-
Vol. 9
Abstract
Dendritic epidermal T cells (DETCs) and dermal Vγ4 T cells engage in wound re-epithelialization and skin inflammation. However, it remains unknown whether a functional link between Vγ4 T cell pro-inflammation and DETC pro-healing exists to affect the outcome of skin wound closure. Here, we revealed that Vγ4 T cell-derived IL-17A inhibited IGF-1 production by DETCs to delay skin wound healing. Epidermal IL-1β and IL-23 were required for Vγ4 T cells to suppress IGF-1 production by DETCs after skin injury. Moreover, we clarified that IL-1β rather than IL-23 played a more important role in inhibiting IGF-1 production by DETCs in an NF-κB-dependent manner. Together, these findings suggested a mechanistic link between Vγ4 T cell-derived IL-17A, epidermal IL-1β/IL-23, DETC-derived IGF-1, and wound-healing responses in the skin.
Keywords
