Tip Lesion Most Frequent FSGS Variant Related to COVID-19 Vaccine: Two Case Reports and Literature Review
Emmy Marjorie Carvalho de Araújo,
Marcos Adriano Garcia Campos,
Andressa Monteiro Sodré,
Maria Izabel de Holanda,
Rodrigo Hagemann,
Antonio Augusto Lima Teixeira Júnior,
Natalino Salgado Filho,
Precil Diego Miranda de Menezes Neves,
Gyl Eanes Barros Silva
Affiliations
Emmy Marjorie Carvalho de Araújo
Faculty of Medicine, Federal University of Maranhão, Gonçalves Dias Square, São Luís 65020-240, Brazil
Marcos Adriano Garcia Campos
Clinical Hospital of Botucatu Medical School, São Paulo State University, Professor Mário Rubens Guimarães Montenegro Avenue, Botucatu 18618-687, Brazil
Andressa Monteiro Sodré
Faculty of Medicine, Federal University of Maranhão, Gonçalves Dias Square, São Luís 65020-240, Brazil
Maria Izabel de Holanda
Bonsucesso Federal Hospital, Londres Avenue, Rio de Janeiro 21041-020, Brazil
Rodrigo Hagemann
Clinical Hospital Complex, Federal University of Paraná, General Carneiro Street, Curitiba 80060-900, Brazil
Antonio Augusto Lima Teixeira Júnior
Departament of Genetics, Ribeirão Preto Medical School, University of São Paulo, Bandeirantes Avenue, Ribeirão Preto 14040-900, Brazil
Natalino Salgado Filho
Faculty of Medicine, Federal University of Maranhão, Gonçalves Dias Square, São Luís 65020-240, Brazil
Precil Diego Miranda de Menezes Neves
Clinical Hospital, University of São Paulo, Dr. Ovídio Pires de Campos Street, São Paulo 05403-010, Brazil
Gyl Eanes Barros Silva
Faculty of Medicine, Federal University of Maranhão, Gonçalves Dias Square, São Luís 65020-240, Brazil
Large-scale COVID-19 vaccination has been one of the most effective strategies to control the spread of the SARS-CoV-2 virus. However, several cases of glomerular injury related to the COVID-19 vaccine have been described in the literature. We report two cases of a tip lesion variant of focal segmental glomerulosclerosis (FSGS), which presented with significant proteinuria and improved after immunosuppression. In our literature review, the tip lesion variant of FSGS is currently the most frequent variant associated with vaccination against COVID-19. Prognosis is favorable and without significant alterations in the tubulointerstitial or vascular compartments. Adverse effects of vaccines need to be recognized early and will help us to understand the immune and pathological mechanisms of kidney damage.
