Metal-polyphenol polymer modified polydopamine for chemo-photothermal therapy

Li Xu; Zhibing Luo; Qing Liu; Chuancui Wang; Fei Zhou; Min Zhou

doi:10.3389/fchem.2023.1124448

Frontiers in Chemistry (Jan 2023)

Metal-polyphenol polymer modified polydopamine for chemo-photothermal therapy

Li Xu,
Zhibing Luo,
Qing Liu,
Chuancui Wang,
Fei Zhou,
Min Zhou

Affiliations

Li Xu: Department of Respiratory Medicine, Jinshan District Central Hospital affiliated to Shanghai University of Medicine & Health Sciences, Shanghai, China
Zhibing Luo: Department of Pulmonary and Critical Care Medicine, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China
Qing Liu: Department of Respiratory Medicine, Jinshan District Central Hospital affiliated to Shanghai University of Medicine & Health Sciences, Shanghai, China
Chuancui Wang: Department of Respiratory Medicine, Jinshan District Central Hospital affiliated to Shanghai University of Medicine & Health Sciences, Shanghai, China
Fei Zhou: Department of Medical Oncology, Shanghai Pulmonary Hospital, Thoracic Cancer Institute, Tongji University School of Medicine, Shanghai, China
Min Zhou: Department of Respiratory Medicine, Jinshan District Central Hospital affiliated to Shanghai University of Medicine & Health Sciences, Shanghai, China

DOI: https://doi.org/10.3389/fchem.2023.1124448
Journal volume & issue: Vol. 11

Abstract

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Chemotherapy combined with photothermal therapy (PTT) is a new way to improve the curative effect of cancer treatment. Here, we developed a multifunctional nanoparticle, namely PTX@mPDA@Fe-GA with the loading of a chemotherapeutic drug paclitaxel (PTX) for targeted and synergistic chemotherapy/photothermal therapy in lung cancer. Fe-gallic acid (Fe-GA) was coated on the surface of mesoporous polydopamine (mPDA) nanoparticles, and then the PTX was placed in the mesopores. The drug release of the loaded PTX exhibited pH- and thermal-dual responsive manner. Both mPDA and Fe-GA have high photothermal conversion ability and play a role in photothermal therapy. In addition, the results revealed that mPDA@Fe-GA had excellent biocompatibility and low hemolysis rate. The PTX-loaded mPDA@Fe-GA not only has excellent killing effect on lung cancer cells (A549) in vitro, but also can significantly suppress the growth of A549 subcutaneous tumor in nude mice. In a nutshell, the developed multifunctional nanoparticles integrate photothermal therapy and efficient chemotherapeutic drug delivery, providing new therapeutic ideas in the fight against lung cancer.

Published in Frontiers in Chemistry

ISSN: 2296-2646 (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Science: Chemistry
Website: http://journal.frontiersin.org/journal/chemistry

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