Nature Communications (Oct 2016)
ARD1-mediated Hsp70 acetylation balances stress-induced protein refolding and degradation
- Ji Hae Seo,
- Ji-Hyeon Park,
- Eun Ji Lee,
- Tam Thuy Lu Vo,
- Hoon Choi,
- Jun Yong Kim,
- Jae Kyung Jang,
- Hee-Jun Wee,
- Hye Shin Lee,
- Se Hwan Jang,
- Zee Yong Park,
- Jaeho Jeong,
- Kong-Joo Lee,
- Seung-Hyeon Seok,
- Jin Young Park,
- Bong Jin Lee,
- Mi-Ni Lee,
- Goo Taeg Oh,
- Kyu-Won Kim
Affiliations
- Ji Hae Seo
- SNU-Harvard NeuroVascular Protection Research Center, College of Pharmacy, Seoul National University
- Ji-Hyeon Park
- SNU-Harvard NeuroVascular Protection Research Center, College of Pharmacy, Seoul National University
- Eun Ji Lee
- SNU-Harvard NeuroVascular Protection Research Center, College of Pharmacy, Seoul National University
- Tam Thuy Lu Vo
- SNU-Harvard NeuroVascular Protection Research Center, College of Pharmacy, Seoul National University
- Hoon Choi
- SNU-Harvard NeuroVascular Protection Research Center, College of Pharmacy, Seoul National University
- Jun Yong Kim
- Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, Seoul National University
- Jae Kyung Jang
- SNU-Harvard NeuroVascular Protection Research Center, College of Pharmacy, Seoul National University
- Hee-Jun Wee
- SNU-Harvard NeuroVascular Protection Research Center, College of Pharmacy, Seoul National University
- Hye Shin Lee
- SNU-Harvard NeuroVascular Protection Research Center, College of Pharmacy, Seoul National University
- Se Hwan Jang
- School of Life Sciences, Gwangju Institute of Science & Technology
- Zee Yong Park
- School of Life Sciences, Gwangju Institute of Science & Technology
- Jaeho Jeong
- Graduate School of Pharmaceutical Sciences, College of Pharmacy, Ewha Womans University
- Kong-Joo Lee
- Graduate School of Pharmaceutical Sciences, College of Pharmacy, Ewha Womans University
- Seung-Hyeon Seok
- The Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University
- Jin Young Park
- The Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University
- Bong Jin Lee
- The Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University
- Mi-Ni Lee
- Department of Life Sciences, Ewha Womans University
- Goo Taeg Oh
- Department of Life Sciences, Ewha Womans University
- Kyu-Won Kim
- SNU-Harvard NeuroVascular Protection Research Center, College of Pharmacy, Seoul National University
- DOI
- https://doi.org/10.1038/ncomms12882
- Journal volume & issue
-
Vol. 7,
no. 1
pp. 1 – 14
Abstract
The chaperone Hsp70 has a dual role, promoting both protein refolding and protein degradation. Seo and Park et al. show that Hsp70 acetylation enhances protein refolding after stress, and that subsequent deacetylation progressively promotes ubiquitin ligase binding and protein degradation.
