Nature Communications (Jan 2022)
Dynamics of spike-and nucleocapsid specific immunity during long-term follow-up and vaccination of SARS-CoV-2 convalescents
- Nina Koerber,
- Alina Priller,
- Sarah Yazici,
- Tanja Bauer,
- Cho-Chin Cheng,
- Hrvoje Mijočević,
- Hannah Wintersteller,
- Samuel Jeske,
- Emanuel Vogel,
- Martin Feuerherd,
- Kathrin Tinnefeld,
- Christof Winter,
- Jürgen Ruland,
- Markus Gerhard,
- Bernhard Haller,
- Catharina Christa,
- Otto Zelger,
- Hedwig Roggendorf,
- Martin Halle,
- Johanna Erber,
- Paul Lingor,
- Oliver Keppler,
- Dietmar Zehn,
- Ulrike Protzer,
- Percy A. Knolle
Affiliations
- Nina Koerber
- Institute of Virology, Helmholtz-Zentrum München/Technical University of Munich, School of Medicine
- Alina Priller
- Institute of Molecular Immunology and Experimental Oncology, Technical University of Munich, School of Medicine
- Sarah Yazici
- Institute of Molecular Immunology and Experimental Oncology, Technical University of Munich, School of Medicine
- Tanja Bauer
- Institute of Virology, Helmholtz-Zentrum München/Technical University of Munich, School of Medicine
- Cho-Chin Cheng
- Institute of Virology, Helmholtz-Zentrum München/Technical University of Munich, School of Medicine
- Hrvoje Mijočević
- Institute of Virology, Helmholtz-Zentrum München/Technical University of Munich, School of Medicine
- Hannah Wintersteller
- Institute of Molecular Immunology and Experimental Oncology, Technical University of Munich, School of Medicine
- Samuel Jeske
- Institute of Virology, Helmholtz-Zentrum München/Technical University of Munich, School of Medicine
- Emanuel Vogel
- Institute of Virology, Helmholtz-Zentrum München/Technical University of Munich, School of Medicine
- Martin Feuerherd
- Institute of Virology, Helmholtz-Zentrum München/Technical University of Munich, School of Medicine
- Kathrin Tinnefeld
- Institute of Virology, Helmholtz-Zentrum München/Technical University of Munich, School of Medicine
- Christof Winter
- Institute of Clinical Chemistry, Technical University of Munich, School of Medicine
- Jürgen Ruland
- Institute of Clinical Chemistry, Technical University of Munich, School of Medicine
- Markus Gerhard
- Institute of Medical Microbiology, Immunology and Hygiene, Technical University of Munich, School of Medicine
- Bernhard Haller
- Institute of Medical Informatics, Statistics and Epidemiology, Technical University of Munich, School of Medicine
- Catharina Christa
- Institute of Virology, Helmholtz-Zentrum München/Technical University of Munich, School of Medicine
- Otto Zelger
- Institute of Sports Medicine, Technical University of Munich, School of Medicine
- Hedwig Roggendorf
- Institute of Molecular Immunology and Experimental Oncology, Technical University of Munich, School of Medicine
- Martin Halle
- Institute of Sports Medicine, Technical University of Munich, School of Medicine
- Johanna Erber
- Department of Internal Medicine II, Technical University of Munich, School of Medicine
- Paul Lingor
- Department of Neurology, Technical University of Munich, School of Medicine
- Oliver Keppler
- German Center for Infection Research (DZIF), Munich partner site
- Dietmar Zehn
- Institute of Animal Physiology and Immunology, Technical University of Munich, School of Life Sciences
- Ulrike Protzer
- Institute of Virology, Helmholtz-Zentrum München/Technical University of Munich, School of Medicine
- Percy A. Knolle
- Institute of Molecular Immunology and Experimental Oncology, Technical University of Munich, School of Medicine
- DOI
- https://doi.org/10.1038/s41467-021-27649-y
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 14
Abstract
Waning immunity to SARS-CoV-2 is of concern. Here the authors follow spike- and nucleocapsid specific immunity in convalescent individuals for 9 months observing a decline in antibody levels but persisting T cell response. Vaccination approximately 11 months after infection boosts antibody and T cell immunity.
