Nature Communications (Jul 2018)

A complex of C9ORF72 and p62 uses arginine methylation to eliminate stress granules by autophagy

  • Maneka Chitiprolu,
  • Chantal Jagow,
  • Veronique Tremblay,
  • Emma Bondy-Chorney,
  • Geneviève Paris,
  • Alexandre Savard,
  • Gareth Palidwor,
  • Francesca A. Barry,
  • Lorne Zinman,
  • Julia Keith,
  • Ekaterina Rogaeva,
  • Janice Robertson,
  • Mathieu Lavallée-Adam,
  • John Woulfe,
  • Jean-François Couture,
  • Jocelyn Côté,
  • Derrick Gibbings

DOI
https://doi.org/10.1038/s41467-018-05273-7
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 18

Abstract

Read online

Many Amyotrophic Lateral Sclerosis (ALS)-linked mutations cause accumulation of stress granules, and most ALS cases are caused by repeat expansions in C9ORF72. Here the authors show that C9ORF72 and the autophagy receptor p62 interact to associate with proteins symmetrically dimethylated on arginines such as FUS, to eliminate stress granules by autophagy.