Frontiers in Immunology (Nov 2020)

Mild SARS-CoV-2 Infection After Gene Therapy in a Child With Wiskott-Aldrich Syndrome: A Case Report

  • Sabina Cenciarelli,
  • Sabina Cenciarelli,
  • Valeria Calbi,
  • Valeria Calbi,
  • Federica Barzaghi,
  • Federica Barzaghi,
  • Maria Ester Bernardo,
  • Maria Ester Bernardo,
  • Maria Ester Bernardo,
  • Chiara Oltolini,
  • Maddalena Migliavacca,
  • Maddalena Migliavacca,
  • Vera Gallo,
  • Vera Gallo,
  • Francesca Tucci,
  • Francesca Tucci,
  • Federico Fraschetta,
  • Federico Fraschetta,
  • Elena Albertazzi,
  • Elena Sophia Fratini,
  • Elena Sophia Fratini,
  • Giulia Consiglieri,
  • Giulia Consiglieri,
  • Stefania Giannelli,
  • Francesca Dionisio,
  • Claudia Sartirana,
  • Sara Racca,
  • Chiara Camesasca,
  • Giovanni Peretto,
  • Giovanni Peretto,
  • Rita Daverio,
  • Antonio Esposito,
  • Antonio Esposito,
  • Francesco De Cobelli,
  • Francesco De Cobelli,
  • Paolo Silvani,
  • Marco Rabusin,
  • Andrea Cara,
  • Daria Trabattoni,
  • Stefania Dispinseri,
  • Gabriella Scarlatti,
  • Lorenzo Piemonti,
  • Vito Lampasona,
  • Maria Pia Cicalese,
  • Maria Pia Cicalese,
  • Alessandro Aiuti,
  • Alessandro Aiuti,
  • Alessandro Aiuti,
  • Francesca Ferrua,
  • Francesca Ferrua

DOI
https://doi.org/10.3389/fimmu.2020.603428
Journal volume & issue
Vol. 11

Abstract

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In this work we present the case of SARS-CoV-2 infection in a 1.5-year-old boy affected by severe Wiskott-Aldrich Syndrome with previous history of autoinflammatory disease, occurring 5 months after treatment with gene therapy. Before SARS-CoV-2 infection, the patient had obtained engraftment of gene corrected cells, resulting in WASP expression restoration and early immune reconstitution. The patient produced specific immunoglobulins to SARS-CoV-2 at high titer with neutralizing capacity and experienced a mild course of infection, with limited inflammatory complications, despite pre-gene therapy clinical phenotype.

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