Antioxidant activity of 2,6-dimethyl-3,5-dialkoxycarbonyl-1,4-dihydropyridines in metal-ion catalyzed lipid peroxidation

Abstract

Antioxidants with 1,4-dihydropyridine structure were investigated as a less harmful alternative to synthetic phenolic antioxidants in liposomes under conditions simulating food storage. The antioxidant activities (AOA) of 2,6-dimethyl-3,5-dialkoxycarbonyl-1,4-dihydropyridines possessing various side chain length alkyls (CH3 - C16H33) in ester moiety were tested in transition metal-ion catalyzed liposome peroxidation and compared with AOA of Trolox™ and Probucol™. The compounds with C2H5 - C4H9 residues in the 3,5-position ester moieties exert the most pronounced AOA. The AOA of tested compounds is associated with their ability to incorporate into liposomes.

Keywords

• 1,4-dihydropyridines
• antioxidants
• metal-ion catalyzed peroxidation