Acetylation of C/EBPα inhibits its granulopoietic function

Deepak Bararia; Hui Si Kwok; Robert S. Welner; Akihiko Numata; Menyhárt B. Sárosi; Henry Yang; Sheena Wee; Sebastian Tschuri; Debleena Ray; Oliver Weigert; Elena Levantini; Alexander K. Ebralidze; Jayantha Gunaratne; Daniel G. Tenen

doi:10.1038/ncomms10968

Nature Communications (Mar 2016)

Acetylation of C/EBPα inhibits its granulopoietic function

Deepak Bararia,
Hui Si Kwok,
Robert S. Welner,
Akihiko Numata,
Menyhárt B. Sárosi,
Henry Yang,
Sheena Wee,
Sebastian Tschuri,
Debleena Ray,
Oliver Weigert,
Elena Levantini,
Alexander K. Ebralidze,
Jayantha Gunaratne,
Daniel G. Tenen

Affiliations

Deepak Bararia: Cancer Science Institute, National University of Singapore
Hui Si Kwok: Cancer Science Institute, National University of Singapore
Robert S. Welner: Harvard Stem Cell Institute, Harvard Medical School
Akihiko Numata: Cancer Science Institute, National University of Singapore
Menyhárt B. Sárosi: Institute of Inorganic Chemistry, Faculty of Chemistry and Mineralogy, Universität Leipzig
Henry Yang: Cancer Science Institute, National University of Singapore
Sheena Wee: Translational Biomedical Proteomics Laboratory, Institute of Molecular and Cell Biology, Agency for Science, Technology and Research
Sebastian Tschuri: Department of Internal Medicine III, University Hospital of the Ludwig-Maximilians-University Munich
Debleena Ray: Program in Cancer and Stem Cell Biology, Duke-NUS Graduate Medical School
Oliver Weigert: Department of Internal Medicine III, University Hospital of the Ludwig-Maximilians-University Munich
Elena Levantini: Dana Farber/Harvard Cancer Center
Alexander K. Ebralidze: Dana Farber/Harvard Cancer Center
Jayantha Gunaratne: Translational Biomedical Proteomics Laboratory, Institute of Molecular and Cell Biology, Agency for Science, Technology and Research
Daniel G. Tenen: Cancer Science Institute, National University of Singapore

DOI: https://doi.org/10.1038/ncomms10968
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 13

Abstract

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C/EBPα is an essential transcription factor for myeloid lineage commitment. Here, the authors show that acetylation of C/EBPα at K298 and K302, mediated at least in part by GCN5, impairs C/EBPα DNA binding ability and modulates C/EBPα transcriptional activity.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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