Bioactivity-Guided Fractionation and Identification of Antidiabetic Compound of <i>Syzygium polyanthum</i> (Wight.)’s Leaf Extract in Streptozotocin-Induced Diabetic Rat Model
Tri Widyawati,
Nor Adlin Yusoff,
Idris Bello,
Mohd Zaini Asmawi,
Mariam Ahmad
Affiliations
Tri Widyawati
Pharmacology and Therapeutics Department, Medical Faculty, Universitas Sumatera Utara, Medan 20155, Indonesia
Nor Adlin Yusoff
Department of Toxicology, Advanced Medical and Dental Institute, Sains@Bertam, Universiti Sains Malaysia, Penang 13200, Malaysia
Idris Bello
Department of Pharmacology, School of Pharmaceutical Sciences, Universiti Sains Malaysia, Penang 11800, Malaysia
Mohd Zaini Asmawi
Department of Pharmacology, School of Pharmaceutical Sciences, Universiti Sains Malaysia, Penang 11800, Malaysia
Mariam Ahmad
Department of Pharmacology, School of Pharmaceutical Sciences, Universiti Sains Malaysia, Penang 11800, Malaysia
(1) Background: An earlier study on the hypoglycemic activity of S. polyanthum (Wight.) leaf methanol extract identified squalene as the major chemical compound. The present study was conducted to assess the hypoglycemic effect of fractions and subfractions of the methanol extract of S. polyanthum compared to the squalene using a bioassay-guided in vivo study. (2) Methods: The methanol extract was fractionated using the liquid–liquid fractionation method. Streptozotocin-induced type 1 diabetic rat was used to study the hypoglycemic effect. (3) Results: The findings showed that chloroform fraction significantly (p p S. polyanthum.
