Synthesis and Biological Evaluation of Triazole linked Thiazolidenone Glycosides

Abstract

In a one pot procedure , a series of novel Triazole linked thiazolidenone derivatives 8 a-g and 9 a-g was prepared by condensation of (3aR,5S,6R,6aR)- 6-((1-(4-fluorophenyl)-1H-1,2,3-triazol-4-yl)methoxy)-2,2-dimethyltetrahydro[2,3-d][1,3]dioxole-5- carbaldehyde 7 with mercapto acids and primary amines in presence of ZnCl2 under both micro wave irradiation and conventional heating conditions. Compound 7 prepared from di Acetone D- Glucose with oxidation followed by reduction , click reaction, primary acetonide deprotection and with oxidative cleavage .Characterization of new compounds has been done by means of IR, NMR, MS and elemental analysis. The nematicidal and anti bacterial activity of the compounds has also been evaluated.

Keywords

• Swern oxidation
• click reaction
• cyclisation
• antimicrobial
• nematicidal activity