NETosis and thrombosis in vaccine-induced immune thrombotic thrombocytopenia

Halina H. L. Leung; Jose Perdomo; Zohra Ahmadi; Shiying S. Zheng; Fairooj N. Rashid; Anoop Enjeti; Stephen B. Ting; James J. H. Chong; Beng H. Chong

doi:10.1038/s41467-022-32946-1

Nature Communications (Sep 2022)

NETosis and thrombosis in vaccine-induced immune thrombotic thrombocytopenia

Halina H. L. Leung,
Jose Perdomo,
Zohra Ahmadi,
Shiying S. Zheng,
Fairooj N. Rashid,
Anoop Enjeti,
Stephen B. Ting,
James J. H. Chong,
Beng H. Chong

Affiliations

Halina H. L. Leung: Haematology Research Unit, School of Clinical Medicine, St George and Sutherland Campus, Faculty of Medicine and Health, University of New South Wales
Jose Perdomo: Haematology Research Unit, School of Clinical Medicine, St George and Sutherland Campus, Faculty of Medicine and Health, University of New South Wales
Zohra Ahmadi: Haematology Research Unit, School of Clinical Medicine, St George and Sutherland Campus, Faculty of Medicine and Health, University of New South Wales
Shiying S. Zheng: Haematology Research Unit, School of Clinical Medicine, St George and Sutherland Campus, Faculty of Medicine and Health, University of New South Wales
Fairooj N. Rashid: Sydney Medical School, Faculty of Medicine and Health, University of Sydney
Anoop Enjeti: Calvary Mater Hospital
Stephen B. Ting: Department of Haematology, Eastern Health and Monash University
James J. H. Chong: Sydney Medical School, Faculty of Medicine and Health, University of Sydney
Beng H. Chong: Haematology Research Unit, School of Clinical Medicine, St George and Sutherland Campus, Faculty of Medicine and Health, University of New South Wales

DOI: https://doi.org/10.1038/s41467-022-32946-1
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 11

Abstract

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The mechanisms underlying the pathogenesis of vaccine-induced immune thrombotic thrombocytopenia (VITT) remain unclear. Here the authors show that anti-PF4 antibodies are responsible for the activation of platelets and neutrophils, and blockage of FcγRIIa or NETosis in vivo can prevent thrombosis.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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