Nature Communications (Jan 2018)
Re-analysis of public genetic data reveals a rare X-chromosomal variant associated with type 2 diabetes
- Sílvia Bonàs-Guarch,
- Marta Guindo-Martínez,
- Irene Miguel-Escalada,
- Niels Grarup,
- David Sebastian,
- Elias Rodriguez-Fos,
- Friman Sánchez,
- Mercè Planas-Fèlix,
- Paula Cortes-Sánchez,
- Santi González,
- Pascal Timshel,
- Tune H. Pers,
- Claire C. Morgan,
- Ignasi Moran,
- Goutham Atla,
- Juan R. González,
- Montserrat Puiggros,
- Jonathan Martí,
- Ehm A. Andersson,
- Carlos Díaz,
- Rosa M. Badia,
- Miriam Udler,
- Aaron Leong,
- Varindepal Kaur,
- Jason Flannick,
- Torben Jørgensen,
- Allan Linneberg,
- Marit E. Jørgensen,
- Daniel R. Witte,
- Cramer Christensen,
- Ivan Brandslund,
- Emil V. Appel,
- Robert A. Scott,
- Jian’an Luan,
- Claudia Langenberg,
- Nicholas J. Wareham,
- Oluf Pedersen,
- Antonio Zorzano,
- Jose C Florez,
- Torben Hansen,
- Jorge Ferrer,
- Josep Maria Mercader,
- David Torrents
Affiliations
- Sílvia Bonàs-Guarch
- Barcelona Supercomputing Center (BSC), Joint BSC-CRG-IRB Research Program in Computational Biology
- Marta Guindo-Martínez
- Barcelona Supercomputing Center (BSC), Joint BSC-CRG-IRB Research Program in Computational Biology
- Irene Miguel-Escalada
- Genomic Programming of Beta-cells Laboratory, Institut d’Investigacions August Pi i Sunyer (IDIBAPS)
- Niels Grarup
- The Novo Nordisk Foundation Center for Basic Metabolic Research, Section for Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen
- David Sebastian
- Instituto de Salud Carlos III, Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM)
- Elias Rodriguez-Fos
- Barcelona Supercomputing Center (BSC), Joint BSC-CRG-IRB Research Program in Computational Biology
- Friman Sánchez
- Barcelona Supercomputing Center (BSC), Joint BSC-CRG-IRB Research Program in Computational Biology
- Mercè Planas-Fèlix
- Barcelona Supercomputing Center (BSC), Joint BSC-CRG-IRB Research Program in Computational Biology
- Paula Cortes-Sánchez
- Barcelona Supercomputing Center (BSC), Joint BSC-CRG-IRB Research Program in Computational Biology
- Santi González
- Barcelona Supercomputing Center (BSC), Joint BSC-CRG-IRB Research Program in Computational Biology
- Pascal Timshel
- The Novo Nordisk Foundation Center for Basic Metabolic Research, Section for Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen
- Tune H. Pers
- The Novo Nordisk Foundation Center for Basic Metabolic Research, Section for Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen
- Claire C. Morgan
- Section of Epigenomics and Disease, Department of Medicine, Imperial College London
- Ignasi Moran
- Section of Epigenomics and Disease, Department of Medicine, Imperial College London
- Goutham Atla
- Genomic Programming of Beta-cells Laboratory, Institut d’Investigacions August Pi i Sunyer (IDIBAPS)
- Juan R. González
- ISGlobal, Centre for Research in Environmental Epidemiology (CREAL)
- Montserrat Puiggros
- Barcelona Supercomputing Center (BSC), Joint BSC-CRG-IRB Research Program in Computational Biology
- Jonathan Martí
- Computer Sciences Department, Barcelona Supercomputing Center (BSC-CNS)
- Ehm A. Andersson
- The Novo Nordisk Foundation Center for Basic Metabolic Research, Section for Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen
- Carlos Díaz
- Computer Sciences Department, Barcelona Supercomputing Center (BSC-CNS)
- Rosa M. Badia
- Computer Sciences Department, Barcelona Supercomputing Center (BSC-CNS)
- Miriam Udler
- Programs in Metabolism and Medical and Population Genetics, Broad Institute of Harvard and MIT
- Aaron Leong
- Diabetes Unit and Center for Genomic Medicine, Massachusetts General Hospital
- Varindepal Kaur
- Diabetes Unit and Center for Genomic Medicine, Massachusetts General Hospital
- Jason Flannick
- Programs in Metabolism and Medical and Population Genetics, Broad Institute of Harvard and MIT
- Torben Jørgensen
- Research Centre for Prevention and Health, Capital Region of Denmark
- Allan Linneberg
- Research Centre for Prevention and Health, Capital Region of Denmark
- Marit E. Jørgensen
- Steno Diabetes Center
- Daniel R. Witte
- Department of Public Health, Aarhus University
- Cramer Christensen
- Medical department, Lillebaelt Hospital
- Ivan Brandslund
- Department of Clinical Biochemistry, Lillebaelt Hospital
- Emil V. Appel
- The Novo Nordisk Foundation Center for Basic Metabolic Research, Section for Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen
- Robert A. Scott
- MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge Biomedical Campus
- Jian’an Luan
- MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge Biomedical Campus
- Claudia Langenberg
- MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge Biomedical Campus
- Nicholas J. Wareham
- MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge Biomedical Campus
- Oluf Pedersen
- The Novo Nordisk Foundation Center for Basic Metabolic Research, Section for Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen
- Antonio Zorzano
- Instituto de Salud Carlos III, Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM)
- Jose C Florez
- Programs in Metabolism and Medical and Population Genetics, Broad Institute of Harvard and MIT
- Torben Hansen
- The Novo Nordisk Foundation Center for Basic Metabolic Research, Section for Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen
- Jorge Ferrer
- Genomic Programming of Beta-cells Laboratory, Institut d’Investigacions August Pi i Sunyer (IDIBAPS)
- Josep Maria Mercader
- Barcelona Supercomputing Center (BSC), Joint BSC-CRG-IRB Research Program in Computational Biology
- David Torrents
- Barcelona Supercomputing Center (BSC), Joint BSC-CRG-IRB Research Program in Computational Biology
- DOI
- https://doi.org/10.1038/s41467-017-02380-9
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 14
Abstract
Genome-wide association studies have uncovered several loci associated with diabetes risk. Here, the authors reanalyse public type 2 diabetes GWAS data to fine map 50 known loci and identify seven new ones, including one near ATGR2 on the X-chromosome that doubles the risk of diabetes in men.
