Nature Communications (Jan 2020)
O-GlcNAcylation of PGK1 coordinates glycolysis and TCA cycle to promote tumor growth
Abstract
Post-translational modifications of phosphoglycerate kinase 1 (PGK1), a glycoytic enzyme, contribute to cancer progression. Here, the authors show that PGK1 is O-GlcNAcylated at T255, which induces its translocation into mitochondria to suppress the tricarboxylic acid cycle for colorectal cancer growth.
