Acute Kidney Injury in Lymphoma: A Single Centre Experience

International Journal of Nephrology. 2014;2014 DOI 10.1155/2014/272961

 

Journal Homepage

Journal Title: International Journal of Nephrology

ISSN: 2090-214X (Print); 2090-2158 (Online)

Publisher: Hindawi Limited

LCC Subject Category: Medicine: Internal medicine: Specialties of internal medicine: Diseases of the genitourinary system. Urology

Country of publisher: United Kingdom

Language of fulltext: English

Full-text formats available: PDF, HTML, ePUB, XML

 

AUTHORS

Muhammad Abdul Mabood Khalil (Section of Nephrology, Department of Medicine, Aga Khan University Hospital, Karachi 74800, Pakistan)
Hira Latif (Section of Nephrology, Department of Medicine, Aga Khan University Hospital, Karachi 74800, Pakistan)
Abdur Rehman (Section of Nephrology, Department of Medicine, Aga Khan University Hospital, Karachi 74800, Pakistan)
Waqar Uddin Kashif (Section of Nephrology, Department of Medicine, Aga Khan University Hospital, Karachi 74800, Pakistan)
Safia Awan (Section of Nephrology, Department of Medicine, Aga Khan University Hospital, Karachi 74800, Pakistan)
Zarghona Khalil (Section of Nephrology, Department of Medicine, Aga Khan University Hospital, Karachi 74800, Pakistan)
Uziar Mushtaq (Section of Nephrology, Department of Medicine, Aga Khan University Hospital, Karachi 74800, Pakistan)
Maria Ahmad (Section of Nephrology, Department of Medicine, Aga Khan University Hospital, Karachi 74800, Pakistan)
Muhammad Ashhad Ullah Khalil (Department of Medicine, Khyber Teaching Hospital, Peshawar 25000, Pakistan)
Manickam Ranga Sami (Department of Nephrology, SSB Hospital, Kuala Belait KA1131, Brunei Darussalam)
Jackson Tan (Department of Nephrology, RIPAS Hospital, Bandar Seri Begawan BA1710, Brunei Darussalam)

EDITORIAL INFORMATION

Blind peer review

Editorial Board

Instructions for authors

Time From Submission to Publication: 17 weeks

 

Abstract | Full Text

Background. Acute kidney injury (AKI) is a common but least studied complication of lymphoma. Objective. To determine the frequency and predictors of AKI in lymphoma and to study the impact of AKI on hospital stay and mortality. Methods. Retrospective review of medical records of hospitalized lymphoma patients aged ≥14 years between January 2008 and December 2011 was done. Results. Out of 365 patients, AKI was present in 31.8% (116/365). Multivariate logistic regression analysis showed that independent predictors for AKI included sepsis (odds ratio (OR) 3.76; 95% CI 1.83–7.72), aminoglycosides (OR 4.75; 95% CI 1.15–19.52), diuretics (OR 2.96; 95% CI 1.31–6.69), tumor lysis syndrome (OR 3.85; 95% CI 1.54–9.59), and R-CVP regimen (OR 4.70; 95% CI 1.20–18.36). AKI stages 2 and 3 was associated with increased hospital stay (OR 2.01; 95% CI 1.19–3.40). Conclusion. AKI was significantly associated with sepsis, aminoglycoside, diuretics, presence of tumor lysis syndrome, and use of R-CVP regimen. Presence of AKIN (Acute Kidney Injury Network) stages 2 and 3 AKI had increased hospital stay. AKI was also associated with increased mortality.