Challenges and future directions of potential natural products leads against 2019-nCoV outbreak

Meirambek Ospanov; Francisco León; Janar Jenis; IKhlas A. Khan; Mohamed A. Ibrahim

Current Plant Biology (Dec 2020)

Challenges and future directions of potential natural products leads against 2019-nCoV outbreak

Meirambek Ospanov,
Francisco León,
Janar Jenis,
IKhlas A. Khan,
Mohamed A. Ibrahim

Affiliations

Meirambek Ospanov: National Center for Natural Products Research, School of Pharmacy, University of Mississippi, University, MS, 38677, USA; The Research Center for Medicinal Plants, Al-Farabi Kazakh National University, Al-Farabi ave. 71, 050040, Almaty, Kazakhstan
Francisco León: Department of Drug Discovery and Biomedical Sciences, College of Pharmacy, University of South Carolina, Columbia, SC, 29208, USA
Janar Jenis: The Research Center for Medicinal Plants, Al-Farabi Kazakh National University, Al-Farabi ave. 71, 050040, Almaty, Kazakhstan
IKhlas A. Khan: National Center for Natural Products Research, School of Pharmacy, University of Mississippi, University, MS, 38677, USA; Corresponding authors at: National Center for Natural Products Research, School of Pharmacy, University of Mississippi, University, MS, 38677, USA.
Mohamed A. Ibrahim: National Center for Natural Products Research, School of Pharmacy, University of Mississippi, University, MS, 38677, USA; Chemistry of Natural Compounds Department, Pharmaceutical and Drug Industries Research Division, National Research Centre, Dokki, 12622, Cairo, Egypt; Corresponding authors at: National Center for Natural Products Research, School of Pharmacy, University of Mississippi, University, MS, 38677, USA.

Journal volume & issue: Vol. 24
p. 100180

Abstract

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Except for Remdesivir® no other drug or vaccine has yet been approved to treat the coronavirus disease (COVID-19) caused by the virus known as, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Remdesivir® an small molecule and nucleic acid analogue, it is used to treat adults and children with laboratory confirmed COVID-19, only administrated in hospital settings. Small molecules and particularly natural products count for almost fifty percent of the commercially available drugs, several of them are marketed antiviral agents and those can be a potential agent to treat COVID-19 infections. This short review rationalized different key natural products with known activity against coronaviruses as potential leads against COVID-19.

Published in Current Plant Biology

ISSN: 2214-6628 (Online)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Science: Botany
Website: http://www.journals.elsevier.com/current-plant-biology/

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