Inhibitor-3 inhibits Protein Phosphatase 1 via a metal binding dynamic protein–protein interaction

Abstract

Protein phosphatase 1 (PP1) is regulated by intrinsically disordered proteins like inhibitor-3, I3. The authors show that I3 does not inhibit PP1 by forming a rigid complex but instead by binding dynamically with its active site metals, showing how flexibility is used in biology.