Nature Communications (Mar 2020)
FAM13A affects body fat distribution and adipocyte function
- Mohsen Fathzadeh,
- Jiehan Li,
- Abhiram Rao,
- Naomi Cook,
- Indumathi Chennamsetty,
- Marcus Seldin,
- Xiang Zhou,
- Panjamaporn Sangwung,
- Michael J. Gloudemans,
- Mark Keller,
- Allan Attie,
- Jing Yang,
- Martin Wabitsch,
- Ivan Carcamo-Orive,
- Yuko Tada,
- Aldons J. Lusis,
- Myung Kyun Shin,
- Cliona M. Molony,
- Tracey McLaughlin,
- Gerald Reaven,
- Stephen B. Montgomery,
- Dermot Reilly,
- Thomas Quertermous,
- Erik Ingelsson,
- Joshua W. Knowles
Affiliations
- Mohsen Fathzadeh
- Department of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine
- Jiehan Li
- Department of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine
- Abhiram Rao
- Department of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine
- Naomi Cook
- Department of Medical Sciences, Molecular Epidemiology, Uppsala University
- Indumathi Chennamsetty
- Department of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine
- Marcus Seldin
- Department of Human Genetics, David Geffen School of Medicine, UCLA
- Xiang Zhou
- Department of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine
- Panjamaporn Sangwung
- Department of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine
- Michael J. Gloudemans
- Department of Genetics, Stanford University
- Mark Keller
- Department of Biochemistry, University of Wisconsin
- Allan Attie
- Department of Biochemistry, University of Wisconsin
- Jing Yang
- Department of Comparative Biosciences, College of Veterinary Medicine, University of Illinois at Urbana–Champaign
- Martin Wabitsch
- Division of Paediatric Endocrinology and Diabetes, Department of Paediatrics and Adolescent Medicine, University of Ulm
- Ivan Carcamo-Orive
- Department of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine
- Yuko Tada
- Department of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine
- Aldons J. Lusis
- Department of Human Genetics, David Geffen School of Medicine, UCLA
- Myung Kyun Shin
- Genetics and Pharmacogenomics, Merck & Co., Inc.
- Cliona M. Molony
- Genetics and Pharmacogenomics, Merck & Co., Inc.
- Tracey McLaughlin
- Stanford Diabetes Research Center, Stanford University
- Gerald Reaven
- Department of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine
- Stephen B. Montgomery
- Stanford Diabetes Research Center, Stanford University
- Dermot Reilly
- Genetics and Pharmacogenomics, Merck & Co., Inc.
- Thomas Quertermous
- Department of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine
- Erik Ingelsson
- Department of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine
- Joshua W. Knowles
- Department of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine
- DOI
- https://doi.org/10.1038/s41467-020-15291-z
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 13
Abstract
Genetic variants in the FAM13A locus have been associated with anthropometric and glycemic traits. Here, using fine-mapping, in vitro knockdown studies in pre-adipocytes and in vivo knockout in mice, the authors show that FAM13A is involved in regulating fat distribution and metabolic traits.
