Low-Temperature Magnesium Calcium Phosphate Ceramics with Adjustable Resorption Rate
Yulia Lukina,
Sergey Kotov,
Leonid Bionyshev-Abramov,
Natalya Serejnikova,
Rostislav Chelmodeev,
Roman Fadeev,
Otabek Toshev,
Alexander Tavtorkin,
Maria Ryndyk,
Dmitriiy Smolentsev,
Nikolay Gavryushenko,
Sergey Sivkov
Affiliations
Yulia Lukina
National Medical Research Center for Traumatology and Orthopedics named after N.N. Priorov, Ministry of Health of the Russian Federation, Ul. Priorova 10, 127299 Moscow, Russia
Sergey Kotov
Building Materials Physico-Chemical Testing Department of the Experimental Tests Preparation and Carry Out Department No. 29, Research Institute of Concrete and Reinforced Concrete (NIIZNB) named after A.A. Gvozdev, JSC Research Center of Construction, Ul. 2 Institutskaya 6, 109428 Moscow, Russia
Leonid Bionyshev-Abramov
National Medical Research Center for Traumatology and Orthopedics named after N.N. Priorov, Ministry of Health of the Russian Federation, Ul. Priorova 10, 127299 Moscow, Russia
Natalya Serejnikova
National Medical Research Center for Traumatology and Orthopedics named after N.N. Priorov, Ministry of Health of the Russian Federation, Ul. Priorova 10, 127299 Moscow, Russia
Rostislav Chelmodeev
National Medical Research Center for Traumatology and Orthopedics named after N.N. Priorov, Ministry of Health of the Russian Federation, Ul. Priorova 10, 127299 Moscow, Russia
Roman Fadeev
The Laboratory of Pharmacological Regulation of Cell Resistance, Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, 142290 Pushchino, Moscow Region, Russia
Otabek Toshev
Department of Materials Science, Lomonosov Moscow State University, Leninskie Gory 1, 119991 Moscow, Russia
Alexander Tavtorkin
A.V. Topchiev Institute of Petrochemical Synthesis, Russian Academy of Sciences, Leninskii Pr. 29, 119991 Moscow, Russia
Maria Ryndyk
A.V. Topchiev Institute of Petrochemical Synthesis, Russian Academy of Sciences, Leninskii Pr. 29, 119991 Moscow, Russia
Dmitriiy Smolentsev
National Medical Research Center for Traumatology and Orthopedics named after N.N. Priorov, Ministry of Health of the Russian Federation, Ul. Priorova 10, 127299 Moscow, Russia
Nikolay Gavryushenko
National Medical Research Center for Traumatology and Orthopedics named after N.N. Priorov, Ministry of Health of the Russian Federation, Ul. Priorova 10, 127299 Moscow, Russia
Sergey Sivkov
Faculty of Technology of Inorganic Substances and High-Temperature Materials, Mendeleev University of Chemical Technology of Russia, Miusskaya Pl. 9, 125047 Moscow, Russia
Low-temperature ceramics based on magnesium calcium phosphate cement are a promising resorbable material for bone tissue restoration with the possibility of functionalization. The replacement of the magnesium Mg2+ ion with a calcium Ca2+ ion at the stage of preparation of the precursor leads to the production of multiphase ceramics containing phases of brushite, monetite, and newberyite, with different dissolution rates. Multiphase ceramics leads to volumetric resorption with preservation of their geometric shape, which was confirmed by the results of an evaluation of the output of magnesium Mg2+ and calcium Ca2+ ions into the contact solution of the ceramics and the X-ray density of ceramic samples during subcutaneous implantation. The combined introduction of sodium pyrophosphate decahydrate and citric acid monohydrate as setting inhibitors neutralizes their insignificant negative effect on the physico-chemical properties of ceramics (strength, pH, porosity), determining the optimal composition. In vivo experiments with setting inhibitors in the composition of ceramics showed a different biological response, affecting the rate of resorption on par with magnesium ions. Preliminary data on biocompatibility and solubility determined magnesium-calcium phosphate ceramics containing additives that regulate setting to be a potential material for bone tissue restoration and a vector for further research, including in orthotopic implantation models.
