Aspirin resistance in patients with ischemic stroke

Abstract

INTRODUCTION[|]Aspirin is the basic agent of antithrombotic treatment in ischemic cerebrovascular disease (CVD) patients. However several patients don't respond to treatment and therefore aspirin resistance term has been used lately. Recent studies have shown that aspirin resistance incidence is between 3-85% among CVD patients. In this study, we aimed to determine the frequency of aspirin resistance in CVD and their relationship with demographic characteristics, risk factors, and stroke subtypes were evaluated. [¤]METHODS[|]In a 6 months period 163 (106 Male-57 Female) acute ischemic stroke patients followed-up and treated with aspirin (100mg-300mg daily) were evaluated. Aspirin resistance was measured by a Multiplate® platelet analyser. Correlation between aspirin resistance and stroke subtypes, age, sex, weight, height, hypertension (HT), diabetes mellitus (DM), history of CVD, smoking, alcohol, hyperlipidemia (HL) and fasting blood glucose level were analyzed.[¤]RESULTS[|]Aspirin resistance was found in 16 male, 9 female, totally 25 (15.3%) of 163 patients. There was no statistically significant relationship between aspirin resistance and stroke-related clinical and laboratory parameters.[¤]DISCUSSION AND CONCLUSION[|]Our results needed to be confirmed with larger prospective trials in order to clarify which of the patients with ischemic stroke should be tested and how to treat the patients with resistance.[¤]

Keywords

• ischemic stroke
• aspirin resistance
• multiplate analyzer