The effect of end-stage renal failure and Cuperphan membrane on several biochemical parameters in hemodialysis patients at Al-Ramadi Teaching Hospital, Iraq

Abstract

Purpose: Dialysis is a common treatment used for patients with chronic kidney disease (CKD), where a dialysis filter is used to remove waste products and excess fluid from the blood. The choice of dialysis filter can significantly impact the biochemical parameters of patients undergoing dialysis. This study aimed to investigate the effect of Cuprophane dialysis filter on the biochemical parameters of 100 chronic kidney disease patients undergoing three consecutive dialysis sessions at Ramadi Teaching Hospital in Iraq.Methods: Blood samples were collected from a total of 200 individuals, including 100 patients with CKD at Al-Ramadi Teaching Hospital in Iraq and 100 control subjects who were matched for age and gender as healthy control group. Samples were taken both before and immediately after three consecutive hemodialysis sessions for the CKD patients. Twenty blood parameters were measured for each sample using standard laboratory methods. The mean and standard deviation (SD) of each parameter were calculated, and ANOVA (Analysis of Variance) were used to determine the significance of differences between pre- and post-dialysis values.Results: Before dialysis, the patients had significantly higher levels of blood urea nitrogen (BUN), creatinine, potassium, glucose, uric acid, and total bilirubin, and significantly lower levels of serum total protein (STP) compared to the control group. After three dialysis sessions, the patients had significantly increased levels of serum cholesterol, triglycerides, amylase, and alkaline phosphatase (ALP), while the D.bilirubin level showed no significant difference compared to the control group.In contrast, after three dialysis sessions, the patients had significantly decreased levels of serum albumin, high-density lipoprotein (HDL), calcium, sodium, aspartate transaminase (AST), alanine transaminase (ALT), and total bilirubin (T.Bilirubin). Furthermore, the results indicated that the Cuprophane dialysis filter had differential effects on the levels of certain parameters before and after dialysis.Specifically, the dialysis membranes increased the levels of lactate dehydrogenase (LDH), decreased the levels of uric acid, serum potassium (S.K+), urea, and chloride (Cl-) to below the values of the control group, and reduced the high levels of Cr and Glu. These reductions brought the levels of creatinine and glucose to the control group levels after dialysis.Conclusion: In conclusion, the use of Cuprophane dialysis filter in chronic kidney disease patients led to significant changes in various biochemical parameters. The results highlight the importance of considering the type of dialysis filter used and monitoring the biochemical parameters of patients undergoing dialysis..

Keywords

• chronic kidney disease
• end stage renal failure
• dialysis filter
• cuperphan membrane
• biochemical parameters