Nature Communications (Oct 2020)

Network-based machine learning in colorectal and bladder organoid models predicts anti-cancer drug efficacy in patients

  • JungHo Kong,
  • Heetak Lee,
  • Donghyo Kim,
  • Seong Kyu Han,
  • Doyeon Ha,
  • Kunyoo Shin,
  • Sanguk Kim

DOI
https://doi.org/10.1038/s41467-020-19313-8
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 13

Abstract

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Cancer patient classification using predictive biomarkers for anti-cancer drug responses is essential for improving therapeutic outcomes. Here, the authors present a machine-learning framework to identify robust drug biomarkers by taking advantage of network-based analyses using pharmacogenomic data.