F1000Research (Nov 2015)

Advances in understanding and managing atopic dermatitis [version 1; referees: 2 approved]

  • Michael Barton,
  • Robert Sidbury

DOI
https://doi.org/10.12688/f1000research.6972.1
Journal volume & issue
Vol. 4

Abstract

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Atopic dermatitis is a chronic, pruritic skin disease characterized by an improperly functioning skin barrier and immune dysregulation. We review proposed atopic dermatitis pathomechanisms, emphasizing how these impact current perspectives on natural history, role of allergic sensitization, and future therapeutic targets.

Keywords