Neurochip3: An Autonomous Multichannel Bidirectional Brain-Computer Interface for Closed-Loop Activity-Dependent Stimulation

Larry E. Shupe; Larry E. Shupe; Frank P. Miles; Geoff Jones; Richy Yun; Jonathan Mishler; Irene Rembado; R. Logan Murphy; Steve I. Perlmutter; Steve I. Perlmutter; Eberhard E. Fetz; Eberhard E. Fetz; Eberhard E. Fetz

doi:10.3389/fnins.2021.718465

Frontiers in Neuroscience (Aug 2021)

Neurochip3: An Autonomous Multichannel Bidirectional Brain-Computer Interface for Closed-Loop Activity-Dependent Stimulation

Larry E. Shupe,
Larry E. Shupe,
Frank P. Miles,
Geoff Jones,
Richy Yun,
Jonathan Mishler,
Irene Rembado,
R. Logan Murphy,
Steve I. Perlmutter,
Steve I. Perlmutter,
Eberhard E. Fetz,
Eberhard E. Fetz,
Eberhard E. Fetz

Affiliations

Larry E. Shupe: Department of Physiology & Biophysics, University of Washington, Seattle, WA, United States
Larry E. Shupe: Washington National Primate Research Center, University of Washington, Seattle, WA, United States
Frank P. Miles: Washington National Primate Research Center, University of Washington, Seattle, WA, United States
Geoff Jones: Independent Researcher, Seattle, CA, United States
Richy Yun: Department of Bioengineering, University of Washington, Seattle, WA, United States
Jonathan Mishler: Department of Bioengineering, University of Washington, Seattle, WA, United States
Irene Rembado: Department of Physiology & Biophysics, University of Washington, Seattle, WA, United States
R. Logan Murphy: Department of Physiology & Biophysics, University of Washington, Seattle, WA, United States
Steve I. Perlmutter: Department of Physiology & Biophysics, University of Washington, Seattle, WA, United States
Steve I. Perlmutter: Washington National Primate Research Center, University of Washington, Seattle, WA, United States
Eberhard E. Fetz: Department of Physiology & Biophysics, University of Washington, Seattle, WA, United States
Eberhard E. Fetz: Washington National Primate Research Center, University of Washington, Seattle, WA, United States
Eberhard E. Fetz: Department of Bioengineering, University of Washington, Seattle, WA, United States

DOI: https://doi.org/10.3389/fnins.2021.718465
Journal volume & issue: Vol. 15

Abstract

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Toward addressing many neuroprosthetic applications, the Neurochip3 (NC3) is a multichannel bidirectional brain-computer interface that operates autonomously and can support closed-loop activity-dependent stimulation. It consists of four circuit boards populated with off-the-shelf components and is sufficiently compact to be carried on the head of a non-human primate (NHP). NC3 has six main components: (1) an analog front-end with an Intan biophysical signal amplifier (16 differential or 32 single-ended channels) and a 3-axis accelerometer, (2) a digital control system comprised of a Cyclone V FPGA and Atmel SAM4 MCU, (3) a micro SD Card for 128 GB or more storage, (4) a 6-channel differential stimulator with ±60 V compliance, (5) a rechargeable battery pack supporting autonomous operation for up to 24 h and, (6) infrared transceiver and serial ports for communication. The NC3 and earlier versions have been successfully deployed in many closed-loop operations to induce synaptic plasticity and bridge lost biological connections, as well as deliver activity-dependent intracranial reinforcement. These paradigms to strengthen or replace impaired connections have many applications in neuroprosthetics and neurorehabilitation.

Published in Frontiers in Neuroscience

ISSN: 1662-4548 (Print); 1662-453X (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Neurosciences. Biological psychiatry. Neuropsychiatry
Website: http://www.frontiersin.org/neuroscience

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Abstract

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