NPC1 regulates ER contacts with endocytic organelles to mediate cholesterol egress

D. Höglinger; T. Burgoyne; E. Sanchez-Heras; P. Hartwig; A. Colaco; J. Newton; C. E. Futter; S. Spiegel; F. M. Platt; E. R Eden

doi:10.1038/s41467-019-12152-2

Nature Communications (Sep 2019)

NPC1 regulates ER contacts with endocytic organelles to mediate cholesterol egress

D. Höglinger,
T. Burgoyne,
E. Sanchez-Heras,
P. Hartwig,
A. Colaco,
J. Newton,
C. E. Futter,
S. Spiegel,
F. M. Platt,
E. R Eden

Affiliations

D. Höglinger: Department of Pharmacology, University of Oxford
T. Burgoyne: UCL Institute of Ophthalmology
E. Sanchez-Heras: UCL Institute of Ophthalmology
P. Hartwig: Heidelberg University Biochemistry Center (BZH)
A. Colaco: Department of Pharmacology, University of Oxford
J. Newton: Department of Biochemistry and Molecular Biology, Virginia Commonwealth University School of Medicine
C. E. Futter: UCL Institute of Ophthalmology
S. Spiegel: Department of Biochemistry and Molecular Biology, Virginia Commonwealth University School of Medicine
F. M. Platt: Department of Pharmacology, University of Oxford
E. R Eden: UCL Institute of Ophthalmology

DOI: https://doi.org/10.1038/s41467-019-12152-2
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 14

Abstract

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Though endocytosed dietary cholesterol is transferred to the endoplasmic reticulum (ER), how this is regulated is unclear. Here, the authors report a role for Niemann-Pick Type C Protein 1 (NPC1) in tethering endocytic organelles to the ER, which may contribute to interorganelle cholesterol transport.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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