Molecules (Oct 2012)

An Efficient Synthesis of Novel Dispirooxindole Derivatives via One-Pot Three-Component 1,3-Dipolar Cycloaddition Reactions

  • Yucheng Wang,
  • Juxian Wang,
  • Hongtao Liu,
  • Huiyuan Wang,
  • Wei Lin,
  • Lexing Xu,
  • Zhibin Huang,
  • Gang Chen,
  • Qian Zhao,
  • Daqing Shi

DOI
https://doi.org/10.3390/molecules171112704
Journal volume & issue
Vol. 17, no. 11
pp. 12704 – 12717

Abstract

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A series of novel dispirooxindoles have been synthesized through three-component 1,3-dipolar cycloaddition of azomethine ylides generated in situ by the decarboxylative condensation of isatin and an α-amino acid with the dipolarophile 5-benzylidene-1,3-dimethylpyrimidine-2,4,6-trione. This method has the advantages of mild reaction conditions, high atom economy, excellent yields, and high regio- and stereo-selectivity.

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