Closed-loop neuromodulation will increase the utility of mouse models in Bioelectronic Medicine

Abstract

Abstract Mouse models have been of tremendous benefit to medical science for the better part of a century, yet bioelectronic medicine research using mice has been limited to mostly acute studies because of a lack of tools for chronic stimulation and sensing. A wireless neuromodulation platform small enough for implantation in mice will significantly increase the utility of mouse models in bioelectronic medicine. This perspective examines the necessary functionality of such a system and the technical challenges needed to be overcome for its development. Recent progress is examined and the outlook for the future of implantable devices for mice is discussed.

Keywords

• Bioelectronic medicine
• Implantable devices
• Neuromodulation
• Mouse model
• Preclinical research
• Engineering challenges