Bactericidal effect of iron oxide nanoparticles on Staphylococcus aureus

Abstract

Nhiem Tran1, Aparna Mir2, Dhriti Mallik2, Arvind Sinha2, Suprabha Nayar2, Thomas J Webster31Department of Physics, Brown University, Providence, Rhode Island, USA; 2Department of Materials Science and Technology, National Metallurgical Laboratory, Burmamnines 831007, Jamshedpur, India; 3Division of  Engineering and Department of Orthopedics, Brown University, Providence, Rhode Island, USAAbstract: In order to study the effects of iron oxide (IO) nanoparticles on Staphylococcus aureus, IO nanoparticles were synthesized via a novel matrix-mediated method using polyvinyl alcohol (PVA). The IO nanoparticles were characterized by transmission electron microscopy and dynamic light scattering. Further, S. aureus were grown in the presence of three different IO nanoparticle concentrations for four, 12, and 24 hours. Live/dead assays were performed and the results provide evidence that IO/PVA nanoparticles inhibited S. aureus growth at thehighest concentration (3 mg/mL) at all time points.Keywords: nanotechnology, drug delivery, bactericide, magnetic nanoparticles