Pharmaciana (May 2014)
PERBANDINGAN EFEKTIVITAS MISOPROSTOL DOSIS 50 µg DAN 100 µg TERHADAP KEBERHASILAN KELAHIRAN INDUKSI DI RSU PKU MUHAMMADIYAH YOGYAKARTA
Abstract
In recent years, misoprostol that is a prostaglandin E1 analogue has been used in cervix ripening at pregnancy and labor induction. However, until now misoprostol dosage and administration route for induction are various. There is no fix guide on administration and dosage of misoprostol. This research was intended to identify profile of misoprostol usage and effectiveness of misoprostol administration at dosage of 50 µg and 100 µg on labor process progress of patient hospitalized in Yogyakarta PKU Muhammadiyah Hospital based on induction success. This research was non experimental research with historical cohort design. Limitation of this method was not all desired data exist in medical record and capability of physician was not same. Subject was pregnant mothers giving birth with misoprostol induction process in delivery room in Yogyakarta PKU Muhammadiyah Hospital from 1 January 2009 to 31 December 2010. Data was obtained from medical record, which was then analyzed descriptively analytically to identify misoprostol usage profile and effectiveness of misoprostol tablet administration at 50 µg and 100 µg dosage on labor process progress. Research subjects who meet the inclusion criteria in this research was 109 mothers, where 69 women (63,30%) got 50 µg misoprostol and 40 women (36,70%) got 100 µg misoprostol. The results of this study indicate that the success of induction at 50 ug misoprostol group decreased by 89% compared with 100 ug misoprostol group (RR = 0.11), where the success of 50 ug misoprostol induction for 56 people from 69 people (81.16%), while the success induction at 100 ug misoprostol group as many as 39 people from 40 people (97.50%). The difference was statistically significant with p = 0.014 (p <0.05).
Keywords
