Role of oxidative stress and endoplasmic reticulum stress in drug-induced liver injury

Abstract

The pathogenesis of drug-induced liver injury (DILI) is still in an early stage of research. However, investigators have shown that both oxidative stress and endoplasmic reticulum (ER) stress play a significant role in the pathological mechanism. However, there is little in-depth literature about these two mechanisms. In order to prevent and improve the clinical symptoms of DILI, it is particularly important to study its pathogenesis. In this review article, the role of ER and oxidative stress in DILI is thoroughly discussed.

Keywords

• reactive nitrogen species
• reactive oxygen species
• endoplasmic reticulum stress
• unfolded protein response
• drug-induced liver injury