Neoadjuvant PD-1 blockade induces T cell and cDC1 activation but fails to overcome the immunosuppressive tumor associated macrophages in recurrent glioblastoma

Alexander H. Lee; Lu Sun; Aaron Y. Mochizuki; Jeremy G. Reynoso; Joey Orpilla; Frances Chow; Jenny C. Kienzler; Richard G. Everson; David A. Nathanson; Steven J. Bensinger; Linda M. Liau; Timothy Cloughesy; Willy Hugo; Robert M. Prins

doi:10.1038/s41467-021-26940-2

Nature Communications (Nov 2021)

Neoadjuvant PD-1 blockade induces T cell and cDC1 activation but fails to overcome the immunosuppressive tumor associated macrophages in recurrent glioblastoma

Alexander H. Lee,
Lu Sun,
Aaron Y. Mochizuki,
Jeremy G. Reynoso,
Joey Orpilla,
Frances Chow,
Jenny C. Kienzler,
Richard G. Everson,
David A. Nathanson,
Steven J. Bensinger,
Linda M. Liau,
Timothy Cloughesy,
Willy Hugo,
Robert M. Prins

Affiliations

Alexander H. Lee: Department of Neurosurgery, University of California, Los Angeles
Lu Sun: Department of Neurosurgery, University of California, Los Angeles
Aaron Y. Mochizuki: Department of Neurosurgery, University of California, Los Angeles
Jeremy G. Reynoso: Department of Neurosurgery, University of California, Los Angeles
Joey Orpilla: Department of Neurosurgery, University of California, Los Angeles
Frances Chow: Department of Neurology/Neuro-Oncology, University of California, Los Angeles
Jenny C. Kienzler: Department of Neurosurgery, University of California, Los Angeles
Richard G. Everson: Department of Neurosurgery, University of California, Los Angeles
David A. Nathanson: Department of Molecular and Medical Pharmacology, University of California, Los Angeles
Steven J. Bensinger: Department of Molecular and Medical Pharmacology, University of California, Los Angeles
Linda M. Liau: Department of Neurosurgery, University of California, Los Angeles
Timothy Cloughesy: Department of Molecular and Medical Pharmacology, University of California, Los Angeles
Willy Hugo: UCLA Jonsson Comprehensive Cancer Center, University of California, Los Angeles
Robert M. Prins: Department of Neurosurgery, University of California, Los Angeles

DOI: https://doi.org/10.1038/s41467-021-26940-2
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 16

Abstract

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Immune-checkpoint blockade has shown limited benefits in patients with glioblastoma. To understand how the composition of the tumor immune microenvironment might limit clinical responses, here the authors present a high dimensional profiling of the immune landscape in patients with glioblastoma following neoadjuvant PD-1 checkpoint blockade.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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