Hyaluronic acid production and characterization by novel Bacillus subtilis harboring truncated Hyaluronan Synthase

Abstract

Key points The strains containing truncated forms of SeHAS enzysme are able to produce HA. The HA from all recombinant strains was the same and low Mw. Deletion of C-terminal region of SeHAS was not effective on Mw.

Keywords

• Bacillus subtilis
• Hyaluronic acid
• Hyaluronan synthase
• Transmembrane domain
• Truncation
• Molecular weight