Nature Communications (May 2020)
A single-cell transcriptomic landscape of primate arterial aging
- Weiqi Zhang,
- Shu Zhang,
- Pengze Yan,
- Jie Ren,
- Moshi Song,
- Jingyi Li,
- Jinghui Lei,
- Huize Pan,
- Si Wang,
- Xibo Ma,
- Shuai Ma,
- Hongyu Li,
- Fei Sun,
- Haifeng Wan,
- Wei Li,
- Piu Chan,
- Qi Zhou,
- Guang-Hui Liu,
- Fuchou Tang,
- Jing Qu
Affiliations
- Weiqi Zhang
- CAS Key Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences
- Shu Zhang
- College of Life Sciences, Peking University
- Pengze Yan
- University of Chinese Academy of Sciences
- Jie Ren
- Biomedical Institute for Pioneering Investigation via Convergence, Peking University
- Moshi Song
- University of Chinese Academy of Sciences
- Jingyi Li
- National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences
- Jinghui Lei
- Beijing Institute for Brain Disorders, Advanced Innovation Center for Human Brain Protection, and National Clinical Research Center for Geriatric Disorders, Xuanwu Hospital Capital Medical University
- Huize Pan
- National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences
- Si Wang
- University of Chinese Academy of Sciences
- Xibo Ma
- University of Chinese Academy of Sciences
- Shuai Ma
- National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences
- Hongyu Li
- National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences
- Fei Sun
- National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences
- Haifeng Wan
- University of Chinese Academy of Sciences
- Wei Li
- University of Chinese Academy of Sciences
- Piu Chan
- Beijing Institute for Brain Disorders, Advanced Innovation Center for Human Brain Protection, and National Clinical Research Center for Geriatric Disorders, Xuanwu Hospital Capital Medical University
- Qi Zhou
- University of Chinese Academy of Sciences
- Guang-Hui Liu
- National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences
- Fuchou Tang
- College of Life Sciences, Peking University
- Jing Qu
- University of Chinese Academy of Sciences
- DOI
- https://doi.org/10.1038/s41467-020-15997-0
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 13
Abstract
Arterial degeneration, closely associated with cardiovascular diseases, is driven by aging-related vascular cell-specific transcriptomics changes. This study provides a single-cell transcriptomic atlas for senile aortic and coronary arteries and underscores FOXO3A-based the transcriptional network in vasoprotection during aging.
