Cross-Sectional Study on Association between Inflammatory Markers and Chest Computed Tomography Severity Score in COVID-19 at Admission

Abstract

Background: The great uncertainty is associated with the disease progression, as the risk of severe COVID-19 is not uniform among all patients.The aim of the work: The aim of this work is to study the association between biomarkers and CT severity score at the time of admission in patients with COVID pneumonia.Patients and Methods: A cross-sectional study was conducted over a period of three months [April 2021 to June 2021] based on data obtained from the records of patients; admitted with laboratory-confirmed SARS-COV-2 infection. The current study included a total of 299 patients; admitted to ICU/COVID ward with COVID-19. Study tools included; serum CRP, serum ferritin, D-dimer, and CT severity score obtained from HRCT chest.Results: The Receiver operation curve [ROC] drawn for D-dimer, Ferritin, and CRP vs. severe lung involvement in HRCT thorax; Area under the curve [AUC] for ferritin - 0.648, AUC for D-dimer - 0.561, AUC for CRP- 0.497. The results suggest that raised serum ferritin is better in the prediction of severity of lung involvement in HRCT than D-dimer and CRP. Serum ferritin [0.171], D-dimer [0.72], and CRP [0.024] are biomarkers with HRCT lung involvement and their corresponding correlation coefficient values.Conclusion: The present study demonstrated a significant correlation between serum ferritin and the severity score of HRCT when compared to other inflammatory markers.

Keywords

• crp
• d-dimer
• serum ferritin
• computed tomography
• covid-19