Assessment of Left Ventricular Structural Remodelling in Patients with Diabetic Cardiomyopathy by Cardiovascular Magnetic Resonance

Journal of Diabetes Research. 2016;2016 DOI 10.1155/2016/4786925

 

Journal Homepage

Journal Title: Journal of Diabetes Research

ISSN: 2314-6745 (Print); 2314-6753 (Online)

Publisher: Hindawi Limited

LCC Subject Category: Medicine: Internal medicine: Specialties of internal medicine: Diseases of the endocrine glands. Clinical endocrinology

Country of publisher: United Kingdom

Language of fulltext: English

Full-text formats available: PDF, HTML, ePUB, XML

 

AUTHORS

Yongning Shang (Department of Radiology, Southwest Hospital, Third Military Medical University, Chongqing 400038, China)
Xiaochun Zhang (Department of Radiology, Southwest Hospital, Third Military Medical University, Chongqing 400038, China)
Liu Chen (Department of Endocrinology, Southwest Hospital, Third Military Medical University, Chongqing 400038, China)
Weiling Leng (Department of Endocrinology, Southwest Hospital, Third Military Medical University, Chongqing 400038, China)
Xiaotian Lei (Department of Endocrinology, Southwest Hospital, Third Military Medical University, Chongqing 400038, China)
Qi Yang (Department of Radiology, Xuanwu Hospital, Beijing 100053, China)
Ziwen Liang (Department of Endocrinology, Southwest Hospital, Third Military Medical University, Chongqing 400038, China)
Jian Wang (Department of Radiology, Southwest Hospital, Third Military Medical University, Chongqing 400038, China)

EDITORIAL INFORMATION

Blind peer review

Editorial Board

Instructions for authors

Time From Submission to Publication: 14 weeks

 

Abstract | Full Text

Background. Diabetic cardiomyopathy (DCM) is always accompanied with alteration of left ventricular structure and function. The aims of this study were to assess the structural remodelling in patients with DCM by cardiovascular magnetic resonance (CMR) and correlation of structural remodelling with severity of DCM. Methods. Twenty-five patients (53.8±8.8 years, 52.0% males) with DCM and thirty-one normal healthy controls (51.9±13.6 years, 45.2% males) were scanned by CMR cine to assess function and structure of left ventricular. Length of diabetic history and results of cardiac echocardiography (E′, A′, and E′/A′) were also measured. Results. Compared with normal controls group, DCM group was associated with significantly increased ratio of left ventricular mass at end diastole to end-diastolic volume (MVR) (P<0.05) and no significant difference was in mass at end diastole (P>0.05). The ratio correlated with both length of diabetic history and echocardiographic Doppler tissue imaging E′ (all P<0.05). Conclusions. CMR can be a powerful technique to assess LV remodelling, and MVR may be considered as an imaging marker to evaluate the severity of LV remodelling in patients with DCM.