Nature Communications (Jan 2018)
Active and dynamic mitochondrial S-depalmitoylation revealed by targeted fluorescent probes
Abstract
S-palmitoylation regulation has been studied mostly in the cytosol and its role in mitochondria is unclear. Here the authors develop fluorescent mitochondria-targeted probes and find that depalmitoylation occurs in mitochondria and it’s influenced by alterations in mitochondrial lipid homeostasis.