Nature Communications (Jan 2018)

Active and dynamic mitochondrial S-depalmitoylation revealed by targeted fluorescent probes

  • Rahul S. Kathayat,
  • Yang Cao,
  • Pablo D. Elvira,
  • Patrick A. Sandoz,
  • María-Eugenia Zaballa,
  • Maya Z. Springer,
  • Lauren E. Drake,
  • Kay F. Macleod,
  • F. Gisou van der Goot,
  • Bryan C. Dickinson

DOI
https://doi.org/10.1038/s41467-017-02655-1
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 14

Abstract

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S-palmitoylation regulation has been studied mostly in the cytosol and its role in mitochondria is unclear. Here the authors develop fluorescent mitochondria-targeted probes and find that depalmitoylation occurs in mitochondria and it’s influenced by alterations in mitochondrial lipid homeostasis.