Nature Communications (May 2019)

Akt and STAT5 mediate naïve human CD4+ T-cell early metabolic response to TCR stimulation

  • Nicholas Jones,
  • Emma E. Vincent,
  • James G. Cronin,
  • Silvia Panetti,
  • Megan Chambers,
  • Sean R. Holm,
  • Sian E. Owens,
  • Nigel J. Francis,
  • David K. Finlay,
  • Catherine A. Thornton

DOI
https://doi.org/10.1038/s41467-019-10023-4
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 13

Abstract

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T-cell subsets differ in metabolic requirements for particular tasks. Here the authors characterize metabolic fluxes in naïve human CD4+ cells upon activation, and identify a role of Stat5 in glutaminolysis linked to IL-2 production.