Partitioning of Cephalexin in Ionic Liquid Aqueous Two-Phase System Composed of 1-Butyl-3-Methylimidazolium Tetrafluoroborate and ZnSO4

Journal of Chemistry. 2013;2013 DOI 10.1155/2013/193671

 

Journal Homepage

Journal Title: Journal of Chemistry

ISSN: 2090-9063 (Print); 2090-9071 (Online)

Publisher: Hindawi Limited

LCC Subject Category: Science: Chemistry

Country of publisher: United Kingdom

Language of fulltext: English

Full-text formats available: PDF, HTML, ePUB

 

AUTHORS

Yan Fang Li (School of Chemistry and Chemical Engineering, Jiangsu University, Zhenjiang 212013, China)
Juan Han (School of Chemistry and Chemical Engineering, Jiangsu University, Zhenjiang 212013, China)
Yun Wang (School of Chemistry and Chemical Engineering, Jiangsu University, Zhenjiang 212013, China)
Jing Jing Ma (School of Biological and Chemical Engineering, Jiangsu University of Science and Technology, Zhenjiang 212003, China)
Yong Sheng Yan (School of Chemistry and Chemical Engineering, Jiangsu University, Zhenjiang 212013, China)

EDITORIAL INFORMATION

Blind peer review

Editorial Board

Instructions for authors

Time From Submission to Publication: 16 weeks

 

Abstract | Full Text

Ionic liquid aqueous two-phase system (ILATPS) was applied in the extraction and separation of hydrosoluble antibiotics. The partitioning behavior of cephalexin (CEX) in 1-butyl-3-methylimidazolium tetrafluoroborate ([Bmim]BF4)-ZnSO4 aqueous two-phase system was studied by the partitioning parameter of the extraction efficiency. The effect of the volume of [Bmim]BF4, the concentration of ZnSO4, temperature, pH, and the volume of ZnSO4 solution was discussed concretely. When the volume of [Bmim]BF4 was 2 mL and the concentration of ZnSO4 was 35%, the extraction efficiency of CEX could reach 92.64% with pH unadjusted. The effect of the volume of [Bmim]BF4 on the extraction efficiency was higher than that of the concentration of ZnSO4. The temperature influenced not only the formation of aqueous two-phase system but also the extraction efficiency of CEX. The target was found to be preferentially extracted to the [Bmim]BF4-rich phase at the pH below 4.3. The partition of CEX to the top phase was enhanced by increasing the volume of [Bmim]BF4, the concentration of ZnSO4, and temperature; however, the partition of CEX to the top phase increased by decreasing the pH.