Datasets for a simulated family-based exome-sequencing study

Abstract

We present simulated exome-sequencing data for 150 families from a North American admixed population, ascertained to contain at least four members affected with lymphoid cancer. These data include information on the ascertained families as well as single-nucleotide variants on the exome of affected family members. We provide a brief overview of the simulation steps and links to the associated software scripts. The resulting data are useful to identify genomic patterns and disease inheritance in families with multiple disease-affected members.

Keywords

• Family studies
• Exome sequencing
• Lymphoid cancer
• Ascertained pedigrees