Nature Communications (Oct 2018)

Gene expression imputation identifies candidate genes and susceptibility loci associated with cutaneous squamous cell carcinoma

  • Nilah M. Ioannidis,
  • Wei Wang,
  • Nicholas A. Furlotte,
  • David A. Hinds,
  • 23andMe Research Team,
  • Carlos D. Bustamante,
  • Eric Jorgenson,
  • Maryam M. Asgari,
  • Alice S. Whittemore

DOI
https://doi.org/10.1038/s41467-018-06149-6
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 9

Abstract

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Genetic loci linked to susceptibility for the common skin cancer cutaneous squamous cell carcinoma (cSCC) have been identified by genome wide association studies (GWAS). Here, the authors impute gene expression levels from GWAS data to perform a transcriptome wide association study (TWAS), identifying five novel genetic loci linked to cSCC susceptibility.