Nature Communications (Aug 2021)
A ligand-insensitive UNC5B splicing isoform regulates angiogenesis by promoting apoptosis
- Davide Pradella,
- Gianluca Deflorian,
- Alex Pezzotta,
- Anna Di Matteo,
- Elisa Belloni,
- Daniele Campolungo,
- Andrea Paradisi,
- Mattia Bugatti,
- William Vermi,
- Matteo Campioni,
- Antonella Chiapparino,
- Luigi Scietti,
- Federico Forneris,
- Costanza Giampietro,
- Nina Volf,
- Michael Rehman,
- Serena Zacchigna,
- Maria Paola Paronetto,
- Anna Pistocchi,
- Anne Eichmann,
- Patrick Mehlen,
- Claudia Ghigna
Affiliations
- Davide Pradella
- Istituto di Genetica Molecolare “Luigi Luca Cavalli-Sforza”, Consiglio Nazionale delle Ricerche
- Gianluca Deflorian
- IFOM, The FIRC Institute of Molecular Oncology
- Alex Pezzotta
- Department of Medical Biotechnology and Translational Medicine, University of Milan—LITA
- Anna Di Matteo
- Istituto di Genetica Molecolare “Luigi Luca Cavalli-Sforza”, Consiglio Nazionale delle Ricerche
- Elisa Belloni
- Istituto di Genetica Molecolare “Luigi Luca Cavalli-Sforza”, Consiglio Nazionale delle Ricerche
- Daniele Campolungo
- Istituto di Genetica Molecolare “Luigi Luca Cavalli-Sforza”, Consiglio Nazionale delle Ricerche
- Andrea Paradisi
- Apoptosis, Cancer and Development Laboratory - Equipe labellisée “La Ligue”, LabEx DEVweCAN, Centre de Recherche en Cancérologie de Lyon, INSERM U1052-CNRS UMR5286, Université de Lyon, Université Claude Bernard Lyon1, Centre Léon Bérard
- Mattia Bugatti
- Department of Molecular and Translational Medicine, University of Brescia
- William Vermi
- Department of Molecular and Translational Medicine, University of Brescia
- Matteo Campioni
- The Armenise-Harvard Laboratory of Structural Biology, Department of Biology and Biotechnology, University of Pavia
- Antonella Chiapparino
- The Armenise-Harvard Laboratory of Structural Biology, Department of Biology and Biotechnology, University of Pavia
- Luigi Scietti
- The Armenise-Harvard Laboratory of Structural Biology, Department of Biology and Biotechnology, University of Pavia
- Federico Forneris
- The Armenise-Harvard Laboratory of Structural Biology, Department of Biology and Biotechnology, University of Pavia
- Costanza Giampietro
- IFOM, The FIRC Institute of Molecular Oncology
- Nina Volf
- Cardiovascular Biology Laboratory, International Centre for Genetic Engineering and Biotechnology (ICGEB), AREA Science Park, Padriciano 99
- Michael Rehman
- Cardiovascular Biology Laboratory, International Centre for Genetic Engineering and Biotechnology (ICGEB), AREA Science Park, Padriciano 99
- Serena Zacchigna
- Cardiovascular Biology Laboratory, International Centre for Genetic Engineering and Biotechnology (ICGEB), AREA Science Park, Padriciano 99
- Maria Paola Paronetto
- Laboratory of Molecular and Cellular Neurobiology, IRCCS Santa Lucia Foundation
- Anna Pistocchi
- Department of Medical Biotechnology and Translational Medicine, University of Milan—LITA
- Anne Eichmann
- Cardiovascular Research Center, Yale University School of Medicine, Department of Internal Medecine Cardiology
- Patrick Mehlen
- Apoptosis, Cancer and Development Laboratory - Equipe labellisée “La Ligue”, LabEx DEVweCAN, Centre de Recherche en Cancérologie de Lyon, INSERM U1052-CNRS UMR5286, Université de Lyon, Université Claude Bernard Lyon1, Centre Léon Bérard
- Claudia Ghigna
- Istituto di Genetica Molecolare “Luigi Luca Cavalli-Sforza”, Consiglio Nazionale delle Ricerche
- DOI
- https://doi.org/10.1038/s41467-021-24998-6
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 17
Abstract
UNC5B is a Netrin-1 receptor expressed in endothelial cells that in the absence of ligand induces apoptosis. Here the authors identify an UNC5B splicing isoform that is insensitive to the pro-survival ligand Netrin-1 and is required for apoptosis-dependent blood vessel development.
