Adaptive Weighted Multiview Kernel Matrix Factorization and Its Application in Alzheimer’s Disease Analysis

Abstract

Recent technology and equipment advancements have provided us with opportunities to better analyze Alzheimer’s disease (AD), where we could collect and employ the data from different image and genetic modalities that may potentially enhance the predictive performance. To perform better clustering in AD analysis, in this paper, we propose a novel model to leverage data from all different modalities/views, which can learn the weights of each view adaptively. Different from previous vanilla Non-negative matrix factorization which assumes data is linearly separable, we propose a simple yet efficient method based on kernel matrix factorization, which is not only able to deal with non-linear data structure but also can achieve better prediction accuracy. Experimental results on the ADNI dataset demonstrate the effectiveness of our proposed method, which indicates promising prospects for kernel application in AD analysis.

Keywords

• adaptive multi-view clustering
• kernel matrix factorization
• Alzheimer’s disease