Invitro activity of Ciprofloxacin Against Gram-negative Bacteria Isolated from Infected Patients in Indonesia.

Abstract

Ciprofloxacin the third generation of the quinolone family was claimed very potent against Gram-negative and Grampositive pathogens compared to former generations. The first in-vitro multi centre study has been conducted in Indonesia including 12 clinical microbiology laboratories as follows: Banda Aceh, Padang, Jakarta, Bandung, Semarang, Yogyakarta, Solo, Surabaya, Malang, Denpasar and Manado. Selected specimens from infected persons were chosen to be included in this study such as from blood, body fluids, bronchial washing, sputum, throat, nose, ear, eye, urethra, vagina, pus, wound, urine and feces. The results of ciprofloxacin disk test technique to all 1457 Gramnegative pathogens showed that between 72 - 98 % were susceptible, while against 22 Acinetobacter sp, only 61 % and againt 19 Neiserria gonorrhoeae only 40 % were susceptible. Results of the agar dilution MIC (Minimum Inhibitory Concentrtion) test were between 69 - 98 % susceptible and the E test technique were between 78 - 100 % susceptible, while against the Acinetobacter were between 61 % and 70 % respectively. N. gonorrhoeae strains was susceptible between 89 % and 92 %.

Keywords

• third generation quinolone
• Gram-positive bacteria
• Gram-negative bacteria