Brain Sciences (Sep 2020)
Genetic Variation and Autism: A Field Synopsis and Systematic Meta-Analysis
- Jinhee Lee,
- Min Ji Son,
- Chei Yun Son,
- Gwang Hun Jeong,
- Keum Hwa Lee,
- Kwang Seob Lee,
- Younhee Ko,
- Jong Yeob Kim,
- Jun Young Lee,
- Joaquim Radua,
- Michael Eisenhut,
- Florence Gressier,
- Ai Koyanagi,
- Brendon Stubbs,
- Marco Solmi,
- Theodor B. Rais,
- Andreas Kronbichler,
- Elena Dragioti,
- Daniel Fernando Pereira Vasconcelos,
- Felipe Rodolfo Pereira da Silva,
- Kalthoum Tizaoui,
- André Russowsky Brunoni,
- Andre F. Carvalho,
- Sarah Cargnin,
- Salvatore Terrazzino,
- Andrew Stickley,
- Lee Smith,
- Trevor Thompson,
- Jae Il Shin,
- Paolo Fusar-Poli
Affiliations
- Jinhee Lee
- Department of Psychiatry, Yonsei University Wonju College of Medicine, Wonju 26426, Korea
- Min Ji Son
- Yonsei University College of Medicine, Seoul 03722, Korea
- Chei Yun Son
- Department of Psychological & Brain Sciences, Washington University in St. Louis, St. Louis, MO 63130, USA
- Gwang Hun Jeong
- College of Medicine, Gyeongsang National University, Jinju 52727, Korea
- Keum Hwa Lee
- Department of Pediatrics, Yonsei University College of Medicine, Seoul 03722, Korea
- Kwang Seob Lee
- Severance Hospital, Yonsei University College of Medicine, Seoul 03722, Korea
- Younhee Ko
- Division of Biomedical Engineering, Hankuk University of Foreign Studies, Gyeonggi-do 17035, Korea
- Jong Yeob Kim
- Yonsei University College of Medicine, Seoul 03722, Korea
- Jun Young Lee
- Department of Nephrology, Yonsei University Wonju College of Medicine, Wonju 26426, Korea
- Joaquim Radua
- Early Psychosis: Interventions and Clinical-detection (EPIC) Lab, Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King’s College London, London SE5 8AB, UK
- Michael Eisenhut
- Department of Pediatrics, Luton & Dunstable University Hospital NHS Foundation Trust, Luton LU4ODZ, UK
- Florence Gressier
- CESP, Inserm UMR1178, Department of Psychiatry, Assistance Publique-Hôpitaux de Paris, Bicêtre University Hospital, 94275 Le Kremlin Bicêtre, France
- Ai Koyanagi
- Research and Development Unit, Parc Sanitari Sant Joan de Déu, Universitat de Barcelona, Fundació Sant Joan de Déu, CIBERSAM, 08830 Barcelona, Spain
- Brendon Stubbs
- Physiotherapy Department, South London and Maudsley NHS Foundation Trust, London SE5 8AZ, UK
- Marco Solmi
- Early Psychosis: Interventions and Clinical-detection (EPIC) Lab, Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King’s College London, London SE5 8AB, UK
- Theodor B. Rais
- Department of Psychiatry, University of Toledo Medical Center, Toledo, OH 43614, USA
- Andreas Kronbichler
- Department of Internal Medicine IV, Medical University Innsbruck, Anichstraße 35, 6020 Innsbruck, Austria
- Elena Dragioti
- Pain and Rehabilitation Centre, and Department of Health, Medicine and Caring Sciences, Linköping University, SE-581 85 Linköping, Sweden
- Daniel Fernando Pereira Vasconcelos
- Laboratory of Histological Analysis and Preparation (LAPHIS), Federal University of the Parnaiba Delta, Parnaiba 64202-020, Brazil
- Felipe Rodolfo Pereira da Silva
- Laboratory of Histological Analysis and Preparation (LAPHIS), Federal University of the Parnaiba Delta, Parnaiba 64202-020, Brazil
- Kalthoum Tizaoui
- Department of Basic Sciences, Medicine Faculty of Tunis, Tunis El Manar University, 15 Rue Djebel Lakdar, Tunis 1007, Tunisia
- André Russowsky Brunoni
- University Hospital, University of São Paulo, São Paulo CEP 05508-000, Brazil
- Andre F. Carvalho
- Centre for Addiction & Mental Health, Toronto, ON M6J 1H4, Canada
- Sarah Cargnin
- Department of Pharmaceutical Sciences and Interdepartmental Research Center of Pharmacogenetics and Pharmacogenomics (CRIFF), University of Piemonte Orientale, 28100 Novara, Italy
- Salvatore Terrazzino
- Department of Pharmaceutical Sciences and Interdepartmental Research Center of Pharmacogenetics and Pharmacogenomics (CRIFF), University of Piemonte Orientale, 28100 Novara, Italy
- Andrew Stickley
- The Stockholm Center for Health and Social Change (SCOHOST), Södertörn University, 141 89 Huddinge, Sweden
- Lee Smith
- The Cambridge Centre for Sport and Exercise Sciences, Anglia Ruskin University, Cambridge CB1 1PT, UK
- Trevor Thompson
- Department of Psychology, University of Greenwich, London SE10 9LS, UK
- Jae Il Shin
- Department of Pediatrics, Yonsei University College of Medicine, Seoul 03722, Korea
- Paolo Fusar-Poli
- Early Psychosis: Interventions and Clinical-detection (EPIC) Lab, Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King’s College London, London SE5 8AB, UK
- DOI
- https://doi.org/10.3390/brainsci10100692
- Journal volume & issue
-
Vol. 10,
no. 10
p. 692
Abstract
This study aimed to verify noteworthy findings between genetic risk factors and autism spectrum disorder (ASD) by employing the false positive report probability (FPRP) and the Bayesian false-discovery probability (BFDP). PubMed and the Genome-Wide Association Studies (GWAS) catalog were searched from inception to 1 August, 2019. We included meta-analyses on genetic factors of ASD of any study design. Overall, twenty-seven meta-analyses articles from literature searches, and four manually added articles from the GWAS catalog were re-analyzed. This showed that five of 31 comparisons for meta-analyses of observational studies, 40 out of 203 comparisons for the GWAS meta-analyses, and 18 out of 20 comparisons for the GWAS catalog, respectively, had noteworthy estimations under both Bayesian approaches. In this study, we found noteworthy genetic comparisons highly related to an increased risk of ASD. Multiple genetic comparisons were shown to be associated with ASD risk; however, genuine associations should be carefully verified and understood.
Keywords
- autism spectrum disorder
- false positive report probability (FPRP)
- Bayesian false-discovery probability (BFDP)
- meta-analysis
- Genome-Wide Association Studies (GWAS)
