A NEW COMPUTER SOFTWARE FOR SIMULATION OF NEURONS

Abstract

In this paper, a new computer software package 'Simulron' for simulation of neurons is introduced. Excitable membranes with voltage-gated ionic channels can be modeled by using the software, and current clamp and voltage clamp experiments can be simulated. The program allows user to determine the ionic channel count and set the rate functions of the channels. If the rate functions are not known, the program enables the user to set steady-state and time constant functions. First-order differential equations used to define dynamics of the gate and membrane potential are solved using forward Euler method of integration with variable time steps. Outputs of the simulations are shown on spreadsheet template allowing flexible data manipulation and can be graphically displayed.

Keywords

• Simülasyon, Nöronal Modelleme, Bilgisayar Yazılımı, Gerilim-Kapılı İyon Kanalları, Uyarılabilir Membranla