(E)-N-(4-(2-(N-benzylidene) hydrazine carbonyl)phenyl)pyridine-4-sulfonamide Schiff bases: Synthesis, spectroscopic characterization, thermo gravimetric analysis and antimicrobial activity

Abstract

A new library of Schiff base scaffolds comprising pyridine sulphonamide moiety were synthesized from typical conventional method by the reaction of Ethyl 4-(N-methyl-pyridine-4-sulphonamide)phenyl hydrazide with different aromatic aldehydes derivatives containing hetero atom under reduced pressure. All the synthesized molecules were obtained with excellent yield especially the compounds containing hetero nucleus and nitrogen analogue. The chemical structures of sulpho-pyridine based schiff base were authenticated by analytical techniques viz. FTIR, 1H NMR, 13C NMR, Mass spectra and Elemental composition. Newly generated compounds were also analyzed for their thermal behavior and found stable below 250 °C. The synthetic analogue was also subjected to screen for their antimicrobial activity against six pathogens. Results revealed that schiff base comprising hetero-atom, Nitro & methoxy group displayed excellent activity while other scaffolds display moderate activity.

Keywords

• Pyridine-sulphonamides
• Schiff bases
• Antimicrobial activity
• Thermogravimetry
• Fungal strain
• Bacterial strain