Communications Biology (Jun 2022)
MALAT1-dependent hsa_circ_0076611 regulates translation rate in triple-negative breast cancer
- Chiara Turco,
- Gabriella Esposito,
- Alessia Iaiza,
- Frauke Goeman,
- Anna Benedetti,
- Enzo Gallo,
- Theodora Daralioti,
- Letizia Perracchio,
- Andrea Sacconi,
- Patrizia Pasanisi,
- Paola Muti,
- Claudio Pulito,
- Sabrina Strano,
- Zaira Ianniello,
- Alessandro Fatica,
- Mattia Forcato,
- Francesco Fazi,
- Giovanni Blandino,
- Giulia Fontemaggi
Affiliations
- Chiara Turco
- Oncogenomic and Epigenetic Unit, IRCCS Regina Elena National Cancer Institute
- Gabriella Esposito
- Oncogenomic and Epigenetic Unit, IRCCS Regina Elena National Cancer Institute
- Alessia Iaiza
- Department of Anatomical, Histological, Forensic and Orthopedic Sciences, Section of Histology and Medical Embryology, Sapienza University of Rome, Laboratory Affiliated to Istituto Pasteur Italia-Fondazione Cenci Bolognetti
- Frauke Goeman
- UOSD SAFU, Department of Research, Advanced Diagnostics, and Technological Innovation, Translational Research Area, IRCCS Regina Elena National Cancer Institute
- Anna Benedetti
- Department of Anatomical, Histological, Forensic and Orthopedic Sciences, Section of Histology and Medical Embryology, Sapienza University of Rome, Laboratory Affiliated to Istituto Pasteur Italia-Fondazione Cenci Bolognetti
- Enzo Gallo
- Department of Pathology, IRCCS Regina Elena National Cancer Institute
- Theodora Daralioti
- Department of Pathology, IRCCS Regina Elena National Cancer Institute
- Letizia Perracchio
- Department of Pathology, IRCCS Regina Elena National Cancer Institute
- Andrea Sacconi
- UOSD Clinical Trial Center, Biostatistics and Bioinformatics, IRCCS Regina Elena National Cancer Institute
- Patrizia Pasanisi
- Unit of Epidemiology and Prevention, Fondazione IRCCS Istituto Nazionale dei Tumori
- Paola Muti
- Department of Health Research Methods, Evidence, and Impact, Faculty of Health Sciences, McMaster University
- Claudio Pulito
- Oncogenomic and Epigenetic Unit, IRCCS Regina Elena National Cancer Institute
- Sabrina Strano
- UOSD SAFU, Department of Research, Advanced Diagnostics, and Technological Innovation, Translational Research Area, IRCCS Regina Elena National Cancer Institute
- Zaira Ianniello
- Department of Biology and Biotechnology “Charles Darwin”, Sapienza University of Rome
- Alessandro Fatica
- Department of Biology and Biotechnology “Charles Darwin”, Sapienza University of Rome
- Mattia Forcato
- Department of Life Sciences, University of Modena and Reggio Emilia
- Francesco Fazi
- Department of Anatomical, Histological, Forensic and Orthopedic Sciences, Section of Histology and Medical Embryology, Sapienza University of Rome, Laboratory Affiliated to Istituto Pasteur Italia-Fondazione Cenci Bolognetti
- Giovanni Blandino
- Oncogenomic and Epigenetic Unit, IRCCS Regina Elena National Cancer Institute
- Giulia Fontemaggi
- Oncogenomic and Epigenetic Unit, IRCCS Regina Elena National Cancer Institute
- DOI
- https://doi.org/10.1038/s42003-022-03539-x
- Journal volume & issue
-
Vol. 5,
no. 1
pp. 1 – 17
Abstract
The circular isoform of VEGFA mRNA (circ_0076611), associated with size and pathogenesis of triple-negative breast tumors, is produced via back splicing of exon-7 by a RNP complex comprising lncRNA-MALAT1, ID4 and SRSF1, and secreted through exosomes.
