Ultrasonographic markers of endometrial receptivity of letrozole and clomiphene citrate in unexplained infertile women

Abstract

Objective: To compare endometrial receptivity of letrozole and clomiphene citrate. Study design: A prospective comparative study. Subjects: 120 women with unexplained infertility undergoing superovulation. Intervention: Sixty patients underwent ovulation induction using 5 mg letrozole compared with another 60 patients using 100 mg clomiphene citrate. Main outcome: The endometrial thickness, the endometrial volume, uterine artery and spiral artery Doppler indices at 7 days after HCG administration. Results: The mean age, parity and duration of infertility in both groups of patients were similar. There was a significant difference in the endometrial thickness, endometrial volume, and spiral artery Doppler indices between the two groups one week after HCG administration. No difference was found in the uterine artery Doppler indices in both groups. The pregnancy rate was higher in the letrozole group but it was statistically insignificant. Conclusion: Letrozole (5 mg) showed a significantly better endometrial response than 100 mg of clomid.

Keywords

• Endometrial receptivity
• Letrozole
• Clomid
• Unexplained infertility