Journal of Vector Borne Diseases (Jun 2012)
Antimalarial potential of Nosode 30 and 200 against Plasmodium berghei infection in Balb/c mice
Abstract
Background & objectives: Homeopathy is considered as an emerging area of alternative medicine which couldbe established for the global health care. One of the greatest objections to this science lies in its inability toexplain the mechanism of action of the micro doses based on scientific experiments and proofs. The presentstudy has been undertaken to screen in vivo antimalarial activity of Malaria Co Nosode 30 and Nosode 200against Plasmodium berghei infection in BALB/c mice.Methods: Peter’s 4-day test was used to evaluate the in vivo schizontocidal effect of Nosode 30 and Nosode 200.One month follow-up study was done to calculate the mean survival time of mice in each group. Biochemicalanalysis was carried out to assess the liver and kidney function tests using diagnostic kits.Results: Nosode 30 and 200 exhibited 87.02 and 37.97% chemosuppression on Day 7 and mean survival time(MST) of 18.5 ± 2.16 and 16.5 ± 1.37 days respectively, which were extremely statistically significant whencompared to MST of infected control (8.55 ± 0.83 days). The safety of Nosode 30 was also confirmed by thecomparable levels of ALP, SGOT, SGPT activities, concentration of bilirubin, urea and creatinine to CQ treatedgroup.Conclusion: Nosode 30 possesses considerable in vivo antiplasmodial activity against P. berghei infection ascompared to Nosode 200 as evident from the chemosuppression obtained using Peter’s 4-day test. Further,studies on the drug can be carried out to establish its antimalarial potential in monotherapy or in combinationwith other homeopathic drug formulations.
