Nature Communications (Feb 2022)
Genomic epidemiology of SARS-CoV-2 in a UK university identifies dynamics of transmission
- Dinesh Aggarwal,
- Ben Warne,
- Aminu S. Jahun,
- William L. Hamilton,
- Thomas Fieldman,
- Louis du Plessis,
- Verity Hill,
- Beth Blane,
- Emmeline Watkins,
- Elizabeth Wright,
- Grant Hall,
- Catherine Ludden,
- Richard Myers,
- Myra Hosmillo,
- Yasmin Chaudhry,
- Malte L. Pinckert,
- Iliana Georgana,
- Rhys Izuagbe,
- Danielle Leek,
- Olisaeloka Nsonwu,
- Gareth J. Hughes,
- Simon Packer,
- Andrew J. Page,
- Marina Metaxaki,
- Stewart Fuller,
- Gillian Weale,
- Jon Holgate,
- Christopher A. Brown,
- The Cambridge Covid-19 testing Centre,
- University of Cambridge Asymptomatic COVID-19 Screening Programme Consortium,
- The COVID-19 Genomics UK (COG-UK) Consortium,
- Rob Howes,
- Duncan McFarlane,
- Gordon Dougan,
- Oliver G. Pybus,
- Daniela De Angelis,
- Patrick H. Maxwell,
- Sharon J. Peacock,
- Michael P. Weekes,
- Chris Illingworth,
- Ewan M. Harrison,
- Nicholas J. Matheson,
- Ian G. Goodfellow
Affiliations
- Dinesh Aggarwal
- University of Cambridge, Department of Medicine
- Ben Warne
- University of Cambridge, Department of Medicine
- Aminu S. Jahun
- University of Cambridge, Department of Pathology, Division of Virology
- William L. Hamilton
- University of Cambridge, Department of Medicine
- Thomas Fieldman
- University of Cambridge, Department of Medicine
- Louis du Plessis
- Department of Zoology, University of Oxford
- Verity Hill
- Institute of Evolutionary Virology, University of Edinburgh
- Beth Blane
- University of Cambridge, Department of Medicine
- Emmeline Watkins
- Public Health Directorate, Cambridgeshire County Council and Peterborough City Council
- Elizabeth Wright
- Public Health Directorate, Cambridgeshire County Council and Peterborough City Council
- Grant Hall
- University of Cambridge, Department of Pathology, Division of Virology
- Catherine Ludden
- University of Cambridge, Department of Medicine
- Richard Myers
- Public Health England
- Myra Hosmillo
- Cambridge University Hospital NHS Foundation Trust
- Yasmin Chaudhry
- University of Cambridge, Department of Pathology, Division of Virology
- Malte L. Pinckert
- University of Cambridge, Department of Pathology, Division of Virology
- Iliana Georgana
- University of Cambridge, Department of Pathology, Division of Virology
- Rhys Izuagbe
- University of Cambridge, Department of Pathology, Division of Virology
- Danielle Leek
- University of Cambridge, Department of Medicine
- Olisaeloka Nsonwu
- Public Health England
- Gareth J. Hughes
- Public Health England
- Simon Packer
- Public Health England
- Andrew J. Page
- Quadram Institute Bioscience, Norwich Research Park
- Marina Metaxaki
- University of Cambridge, Department of Medicine
- Stewart Fuller
- University of Cambridge, Department of Medicine
- Gillian Weale
- Health, Safety & Regulated Facilities Division, University of Cambridge
- Jon Holgate
- University Information Services, University of Cambridge
- Christopher A. Brown
- Cambridge Covid-19 Testing Centre, Discovery Sciences, R&D, AstraZenenca
- The Cambridge Covid-19 testing Centre
- University of Cambridge Asymptomatic COVID-19 Screening Programme Consortium
- The COVID-19 Genomics UK (COG-UK) Consortium
- Rob Howes
- Cambridge Covid-19 Testing Centre, Discovery Sciences, R&D, AstraZenenca
- Duncan McFarlane
- Institute for Manufacturing, University of Cambridge
- Gordon Dougan
- University of Cambridge, Department of Medicine
- Oliver G. Pybus
- Department of Zoology, University of Oxford
- Daniela De Angelis
- Public Health England
- Patrick H. Maxwell
- University of Cambridge, Department of Medicine
- Sharon J. Peacock
- University of Cambridge, Department of Medicine
- Michael P. Weekes
- Cambridge University Hospital NHS Foundation Trust
- Chris Illingworth
- MRC Biostatistics Unit, University of Cambridge
- Ewan M. Harrison
- University of Cambridge, Department of Medicine
- Nicholas J. Matheson
- University of Cambridge, Department of Medicine
- Ian G. Goodfellow
- University of Cambridge, Department of Pathology, Division of Virology
- DOI
- https://doi.org/10.1038/s41467-021-27942-w
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 16
Abstract
In this study, Aggarwal and colleagues perform prospective sequencing of SARS-CoV-2 isolates derived from asymptomatic student screening and symptomatic testing of students and staff at the University of Cambridge. They identify important factors that contributed to within university transmission and onward spread into the wider community.
